… number of mutations are well … across SARS-related coronaviruses. However, we find no
evidence that these ACE2-affinity-enhancing mutations have been selected in current SARS-CoV…

… mutations in the viral spike protein. Here, we describe a deep mutational scanning platform
… how large numbers of spike mutations impact antibody neutralization and pseudovirus …

… how thousands of mutations to the spike glycoprotein of recent SARS-CoV-2 strains … deep
mutational scanning system 4 that enables safe experimental characterization of mutations …

… pseudotyped lentivirus deep mutational scanning system 4 that enables safe experimental
characterization of mutations throughout the spike 5 . We demonstrate that mutations outside …

… point mutations using a mammalian surface-display platform and deep mutational scanning.
… their susceptibility to mutational escape. Our data predict no vulnerabilities for detection of …

… mutations and indels observed among 17 SARS-CoV-2 major variants using our deep mutational
scanning … Among these 17 variants, there are 25 different amino acid mutations and 25 …

… deep mutational scanning (DMS) experiments on an S2 region spanning the fusion peptide
of authentic SARS-CoV… We identify mutations at residue 813 of the spike protein that reduced …

… We hypothesized that deep mutational scanning could identify mutations that improve the …
most of the 8 mutations were stabilizing. Deep mutational scanning could then identify the …

… (2021a) have mapped all the mutations to the RBD that escape binding by antibodies … Their
yeast-display deep mutational scanning revealed that antibodies were escaped by mutations …

… We performed deep mutational scanning experiments to characterize the functional impacts
of all single mutations in the Omicron BA.1 and BA.2 RBDs on ACE2-binding affinity and …