Inhibitors of prolyl oligopeptidases for the therapy of human diseases: defining diseases and inhibitors
J Lawandi, S Gerber-Lemaire… - Journal of medicinal …, 2010 - ACS Publications
… Proline-Specific Endopeptidases: Prolyl Oligopeptidases (POPs) Prolyl oligopeptidases …
(24, 25) before they were named prolyl oligopeptidases. The POP enzyme family evolved before …
(24, 25) before they were named prolyl oligopeptidases. The POP enzyme family evolved before …
Structure, function and biological relevance of prolyl oligopeptidase
L Polgar, Z Szeltner - Current Protein and Peptide Science, 2008 - ingentaconnect.com
… The crystal structure of prolyl oligopeptidase (POP) has shown that … POP and to treat
neurological disorders. Other studies concerned … modified or at defined secondary structures [136]. …
neurological disorders. Other studies concerned … modified or at defined secondary structures [136]. …
The prolyl oligopeptidase family
L Polgar - Cellular and Molecular Life Sciences CMLS, 2002 - Springer
… in the amyloid-related etiology of Alzheimer disease is not supported by other findings
indicating that specific inhibitors do not affect the formation and degradation of bamyloid peptides …
indicating that specific inhibitors do not affect the formation and degradation of bamyloid peptides …
Structure-function of prolyl oligopeptidase and its role in neurological disorders
L Polgár - … Medicinal Chemistry-Central Nervous System Agents, 2002 - ingentaconnect.com
… The activity of prolyl oligopeptidase in … , prolyl oligopeptidase is implicated in a variety of
disorders of the central nervous system. For example, a decrease in serum prolyl oligopeptidase …
disorders of the central nervous system. For example, a decrease in serum prolyl oligopeptidase …
Prolyl oligopeptidase: a rising star on the stage of neuroinflammation research
A Penttinen, J Tenorio-Laranga… - … Disorders-Drug …, 2011 - ingentaconnect.com
… Prolyl oligopeptidase (POP) cleaves short peptides at the C-… Despite all research done to
define the role of POP in … that POP has a role in diseases that have a notable inflammatory and/…
define the role of POP in … that POP has a role in diseases that have a notable inflammatory and/…
New tricks of prolyl oligopeptidase inhibitors–a common drug therapy for several neurodegenerative diseases
R Svarcbahs, U Julku, T Kilpeläinen, M Kyyrö… - Biochemical …, 2019 - Elsevier
Abstract Changes in prolyl oligopeptidase (PREP) expression levels, protein distribution,
and activity correlate with aging and are reported in many neurodegenerative conditions. …
and activity correlate with aging and are reported in many neurodegenerative conditions. …
Structure and function relationship in prolyl oligopeptidase
R Van Elzen, AM Lambeir - CNS & Neurological Disorders …, 2011 - ingentaconnect.com
… Ribbon diagram of porcine prolyl oligopeptidase complexed with Abz-Gly-Phe-Gly-Pro-Phe-…
Ligand binding site of the inactive Ser554Ala variant of prolyl oligopeptidase in complex with …
Ligand binding site of the inactive Ser554Ala variant of prolyl oligopeptidase in complex with …
[HTML][HTML] Mechanism of action of prolyl oligopeptidase (PREP) in degenerative brain diseases: has peptidase activity only a modulatory role on the interactions of …
PT Männistö, JA García-Horsman - Frontiers in aging neuroscience, 2017 - frontiersin.org
… Prolyl oligopeptidase (PREP) is a protein highly expressed in brain, … defined, and after
intense research, the molecular mechanisms where this protein is involved have not been defined…
intense research, the molecular mechanisms where this protein is involved have not been defined…
[HTML][HTML] The dipeptidyl peptidase family, prolyl oligopeptidase and prolyl carboxypeptidase in the immune system and inflammatory disease, including atherosclerosis
Y Waumans, L Baerts, K Kehoe, AM Lambeir… - Frontiers in …, 2015 - frontiersin.org
… on the role of prolyl-specific peptidases DPPIV, FAP, DPP8, DPP9, dipeptidyl peptidase II,
prolyl carboxypeptidase, and prolyl oligopeptidase in the immune system and its diseases. We …
prolyl carboxypeptidase, and prolyl oligopeptidase in the immune system and its diseases. We …
Prolyl oligopeptidase and its role in the organism: attention to the most promising and clinically relevant inhibitors
K Babkova, J Korabecny, O Soukup… - Future medicinal …, 2017 - Future Science
… Prolyl oligopeptidase (POP), also called prolyl endopeptidase, … and Parkinson's diseases
as well as other diseases related to … More research needs be stimulated to precisely define …
as well as other diseases related to … More research needs be stimulated to precisely define …