… of the involvement of cytokines in neurodegenerative disorders and their potential … pro-inflammatory
cytokines merit interest as targets in the treatment of neurodegenerative disorders…

… In addition, proinflammatory cytokines (through a variety of … of neurodegenerative disorders
(eg, Alzheimer disease).The aim … of the activity of proinflammatory cytokines implicated in the …

… degenerative diseases characterized by chronic inflammation to switch from proinflammatory
… Whether proinflammatory microglia are harmful or beneficial may depend upon the degree …

… as it relates to CNS proinflammatory cytokine production. We … isoforms in the production of
proinflammatory cytokines. We … , especially p38α, in cytokine production. Finally, we discuss …

… IL-1 is a well-characterized proinflammatory cytokine that has been implicated in several
chronic degenerative disease processes, including the development of atherosclerosis and …

… This impairs the phagocytotic capacity of microglia and increases the expression of pro-inflammatory
cytokines. In mouse models of AD, appropriate microglial functioning supports …

… Alzheimer’s disease (AD) is a progressive neurodegenerative disorder of the brain, which
is characterized by the formation of extracellular amyloid plaques (or senile plaques) and …

… as representing degenerative disc disease or herniated IVD (Table 1), with no differences
in BMI or sex distribution between pathology groups. Patients with degenerative disc disease …

… reaction products in neurodegenerative diseases. The … , such as proinflammatory
cytokine-mediated cascades, … of the major differences in neurodegenerative diseases. This …

… of adhesion molecules (VCAM-1 and ICAM-1) in vascular endothelial cells and promotes
the synthesis and secretion of proinflammatory cytokines such as TNF-α, IL-6 and IL-12. …