Efficacy and safety of delamanid in combination with an optimised background regimen for treatment of multidrug-resistant tuberculosis: a multicentre, randomised …

F von Groote-Bidlingmaier, R Patientia… - The Lancet …, 2019 - thelancet.com
… to delamanid plus optimised background regimen [delamanid group] and 170 to placebo
plus optimised background regimen [… population (226 in the delamanid group and 101 in the …

Delamanid added to an optimized background regimen in children with multidrug-resistant tuberculosis: results of a phase I/II clinical trial

AJ Garcia-Prats, M Frias, L van der Laan… - Antimicrobial agents …, 2022 - Am Soc Microbiol
… , and preliminary efficacy of delamanid when combined with optimized background regimen
(OBR) in children (birth to 17 years) with MDR-TB. Delamanid administered at 100 mg twice-…

Delamanid improves outcomes and reduces mortality in multidrug-resistant tuberculosis

V Skripconoka, M Danilovits, L Pehme… - European …, 2013 - Eur Respiratory Soc
… This analysis suggests that treatment with delamanid for 6 months in combination with an
optimised background regimen can improve outcomes and reduce mortality among patients …

Early safety and efficacy of the combination of bedaquiline and delamanid for the treatment of patients with drug-resistant tuberculosis in Armenia, India, and South …

G Ferlazzo, E Mohr, C Laxmeshwar… - The Lancet Infectious …, 2018 - thelancet.com
… the use of combination bedaquiline and delamanid for people … of regimens containing
the bedaquiline and delamanid … and delamanid in combination even if background MDR …

Early experience with delamanid-containing regimens in the treatment of complicated multidrug-resistant tuberculosis in Hong Kong

KC Chang, ECC Leung, WS Law… - European …, 2018 - Eur Respiratory Soc
… The combined use of bedaquiline and delamanid has been … adding delamanid to an
optimised background regimen when … control group than inadequate delamanid exposure, which …

Delamanid: a review of its use in patients with multidrug-resistant tuberculosis

HA Blair, LJ Scott - Drugs, 2015 - Springer
Delamanid has been approved in the EU and Japan for the … combination with an optimized
background regimen (OBR). This article reviews the pharmacological properties of delamanid

Comparative effectiveness of adding delamanid to a multidrug-resistant tuberculosis regimen comprised of three drugs likely to be effective

CA Rodriguez, S Lodi, CR Horsburgh… - PLOS Global Public …, 2023 - journals.plos.org
… In regimens containing combinations of three likely … delamanid plus a background regimen
of three drugs versus initiating a background regimen of three drugs, not including delamanid

[HTML][HTML] Delamanid-containing regimens and multidrug-resistant tuberculosis: A systematic review and meta-analysis

MJ Nasiri, M Zangiabadian, E Arabpour, S Amini… - International Journal of …, 2022 - Elsevier
… Optimized background regimens (OBR) were concomitantly prescribed with DLM. Basically,
… In the studies selected the best regimen was tailored on the patient's characteristics and was …

Safety of treatment regimens containing bedaquiline and delamanid in the endTB cohort

C Hewison, U Khan, M Bastard… - Clinical Infectious …, 2022 - academic.oup.com
… and delamanid. MDR-TB treatment monitoring and drug durations should reflect expected
safety profiles of drug combinations. … and delamanid used in drug-resistant TB regimens in the …

Bedaquiline and delamanid in the treatment of multidrug‐resistant tuberculosis: Promising but challenging

Y Li, F Sun, W Zhang - Drug development research, 2019 - Wiley Online Library
… on delamanid and showed that introducing delamanid to a background regimen improved
… Studies on the combination of bedaquiline and delamanid will be discussed later in this …