Immediate hypothermia is not neuroprotective after severe hypoxia-ischemia and is deleterious when delayed by 12 hours in neonatal rats

H Sabir, E Scull-Brown, X Liu, M Thoresen - Stroke, 2012 - Am Heart Assoc
… Hypothermia (HT) for neonatal hypoxic-ischemic encephalopathy is advised to start within …
than against severe hypoxic-ischemic encephalopathy, but it is unknown whether delayed HT …

Delayed effects of severe hypoxia experienced by marine gastropod embryos

CJ Segura, OR Chaparro, JA Pechenik… - Marine Ecology …, 2014 - int-res.com
… per female and severely compromised juvenile growth and … of severe hypoxic conditions
can have a dramatic impact on early development and reproductive fitness, with some effects

Delayed cerebral atrophy following moderate hypoxia-ischemia in the immature rat

R Geddes, RC Vannucci, SJ Vannucci - Developmental neuroscience, 2001 - karger.com
… This study examined the effects of both severe and moderate duration of H/I on the evolution
of damage through 8 weeks of recovery. Seven-day-old rat pups were subjected to either …

Excitotoxicity in neonatal hypoxia

MV Johnston - Mental retardation and developmental …, 2001 - Wiley Online Library
… Caspase inhibitor affords neuroprotection after delayed administration in a rat model of
neonatal hypoxic-ischemic brain injury. J Clin Invest 101:1992–1999. Choi DW, Rothman SM. …

Moderate and severe hypoxia elicit divergent effects on cardiovascular function and physiological rhythms

MA Allwood, BA Edgett, AL Eadie… - The Journal of …, 2018 - Wiley Online Library
… suddenly and dramatically decreased SBP, whereas moderate hypoxia resulted in a delayed
and gradual decrease. This might be explained by differential alternations in the circadian …

[HTML][HTML] Mild hypothermia after severe transient hypoxia-ischemia reduces the delayed rise in cerebral lactate in the newborn piglet

PN Amess, J Penrice, EB Cady, A Lorek… - Pediatric …, 1997 - nature.com
… The severity of the primary insult (judged from the time integral of depletion of [NTP]/[EPP]) …
after a severe acute cerebral hypoxic-ischemic insult reduces the delayed elevation in lactate …

The effect of hypoxia in development

WS Webster, D Abela - Birth Defects Research Part C: Embryo …, 2007 - Wiley Online Library
… The use of hypoxia probes in mammalian embryos during the … of partial hypoxia, and this
may be essential to control cardiovascular development, perhaps under the control of hypoxia‐…

Delayed hypoxemia after traumatic brain injury exacerbates long-term behavioral deficits

MK Davies, A Jacobs, DL Brody… - Journal of neurotrauma, 2018 - liebertpub.com
hypoxemia and brain hypoxia occurring in the intensive care setting. Understanding long-term
effects of delayed hypoxemia … therapeutics targeting secondary brain hypoxia. For this …

[HTML][HTML] Severe hypoxemia: which strategy to choose

D Chiumello, M Brioni - Critical Care, 2016 - Springer
… -to-severe ARDS or in the presence of other organ failure, noninvasive ventilatory support
presents a high risk of failure: in those cases the risk/benefit of delayed mechanical ventilation …

“Therapeutic time window” duration decreases with increasing severity of cerebral hypoxia–ischaemia under normothermia and delayed hypothermia in newborn …

O Iwata, S Iwata, JS Thornton, E De Vita, A Bainbridge… - Brain research, 2007 - Elsevier
… The influences of HI severity on latent-phase duration and regional neuroprotection … delayed
whole-body cooling to 35 and 33 C we aimed to assess relationships between HI severity