Induction of dendritic cell differentiation by IFN-α in systemic lupus erythematosus

P Blanco, AK Palucka, M Gill, V Pascual, J Banchereau - Science, 2001 - science.org
… alterations in the function of dendritic cells (DCs), because these cells are key regulators of
the … cells (APCs) capable of inducing activation of naı̈ve T cells (10, 11) and of stimulating B …

[PDF][PDF] Natural interferon-α producing cells: the plasmacytoid dendritic cells

P Fitzgerald-Bocarsly - Biotechniques, 2002 - Taylor & Francis
… (23) in which dendritic cells were isolated after overnight culture demonstrated that these
more mature dendritic cells were not functional NIPCs. However, since IFN-α producing …

A pivotal role for the natural interferon α–producing cells (plasmacytoid dendritic cells) in the pathogenesis of lupus

L Rönnblom, GV Alm - The Journal of experimental medicine, 2001 - rupress.org
… . Type I interferon as a powerful adjuvant for monocyte-derived dendritic cell development
and … oligonucleotide sequences with high induction of IFN-α/β in plasmacytoid dendritic cells. …

The central role of dendritic cells and interferon-α in SLE

V Pascual, J Banchereau… - Current opinion in …, 2003 - journals.lww.com
… the fundamental role of dendritic cells in the … dendritic cell activation. This review summarizes
the recently uncovered role of dendritic cell subsets and one of their products, interferon-α, …

Differential responses to IFN-α subtypes in human T cells and dendritic cells

CMU Hilkens, JF Schlaak, IM Kerr - The Journal of Immunology, 2003 - journals.aai.org
… In particular, IFN-γ-inducible protein-10 (IP-10), a key chemokine in Th1-type inflammatory …
In dendritic cells, it was highly induced by IFN-α2 and IFN-α21 but much less efficiently by IFN-…

Identification of CpG oligonucleotide sequences with high induction of IFNα/β in plasmacytoid dendritic cells

A Krug, S Rothenfusser, V Hornung… - European journal of …, 2001 - Wiley Online Library
… plasmacytoid dendritic cell (PDC) is identical with the principal type I IFN-producing cell
upon … that strongly activate human B cells and human blood dendritic cells. Here we describe …

Expression of the markers BDCA‐2 and BDCA‐4 and production of interferonα by plasmacytoid dendritic cells in systemic lupus erythematosus

S Blomberg, ML Eloranta, M Magnusson… - … : Official Journal of …, 2003 - Wiley Online Library
… blood dendritic cell antigen 2 (BDCA‐2) and BDCA‐4 molecules by plasmacytoid dendritic
cells (… of interferonα (IFNα) and its inhibition by anti–BDCA‐2 and anti–BDCA‐4 antibodies. …

… is expressed on natural IFN-α-producing cells (plasmacytoid dendritic cells) and is required for the IFN-α production induced by apoptotic cells combined with lupus …

…, M Magnusson, ML Eloranta, A Perers… - The Journal of …, 2003 - journals.aai.org
IFN-α producers that constitute ∼1/1000 of all PBMC and upon stimulation produce large
amounts of IFN-α (1–2 U/cell). … The phenotype is that of an immature dendritic cell (DC) (29), …

Comparative analysis of IRF and IFN-alpha expression in human plasmacytoid and monocyte-derived dendritic cells

A Izaguirre, BJ Barnes, S Amrute… - Journal of Leucocyte …, 2003 - academic.oup.com
… type I IFN production in myeloid and dendritic cell populations, we analyzed expression of
IRF genes by semiquantitative RT-PCR in mock-stimulated and virus-stimulated cells. Primers …

IFN-α skews monocytes into CD56+-expressing dendritic cells with potent functional activities in vitro and in vivo

C Papewalis, B Jacobs, M Wuttke, E Ullrich… - The Journal of …, 2008 - journals.aai.org
… The antitumor effect of IFN-α is mediated by the activation of CTLs, NK cells, and the generation
of highly potent Ag-presenting dendritic cells (IFN-DCs). In this study, we show that IFN-…