Logical modelling of in vitro differentiation of human monocytes into dendritic cells unravels novel transcriptional regulatory interactions

KJ Nuñez-Reza, A Naldi… - Interface …, 2021 - royalsocietypublishing.org
… (DCs) are the major specialized antigen-presenting cells, … we established a preliminary
logical model that helped us identify … between TFs that compose our final logical model. Figure 3. …

Logical model of human tolerogenic dendritic cells and their participation in autoimmune disease

KJ Nuñez-Reza, I Lozano-Jiménez… - bioRxiv, 2023 - biorxiv.org
… Here we built a logical model for the tolerization cellular process of dendritic cells using IL10…
and key tolDC markers, we ensembled a logical model that describes the obtention of tolDC …

[HTML][HTML] A multiscale mechanistic model of human dendritic cells for in-silico investigation of immune responses and novel therapeutics discovery

SS Aghamiri, BL Puniya, R Amin, T Helikar - Frontiers in Immunology, 2023 - frontiersin.org
… Our logical model consists of 281 components that connect … involved in dendritic cells
and antigen-presenting cells, we … : “dendritic cells AND antigen-presenting cell AND MoDC …

Logical modeling of dendritic cells in vitro differentiation from human monocytes unravels novel transcriptional regulatory interactions

KJ Nuñez-Reza, A Naldi, A Sanchéz-Jiménez… - bioRxiv, 2020 - biorxiv.org
… Monocytes can differentiate into dendritic cells in vitro in the … regulation responsible for
dendritic cell differentiation from … , we established a preliminary logical model that helped us …

[HTML][HTML] Multi-level computational Modeling of anti-Cancer dendritic cell vaccination utilized to select molecular targets for therapy optimization

X Lai, C Keller, G Santos, N Schaft, J Dörrie… - Frontiers in cell and …, 2022 - frontiersin.org
Dendritic cells (DCs) are the strongest stimulators of our immune response (Fong and …
Finally, we included a model module accounting for T cell activation by DCs in the spleen. The …

[HTML][HTML] Dynamical Boolean Modeling of Immunogenic Cell Death

A Checcoli, JG Pol, A Naldi, V Noel, E Barillot… - Frontiers in …, 2020 - frontiersin.org
… bnd file containing the logical rules and the definition … model. (A) Influence network of the
extended version of ICD involving four cell types: tumor cells (light purple nodes), dendritic cells

Optimal treatment strategies using dendritic cell vaccination for a tumor model with parameter identifiability

S Khajanchi, J Mondal, PK Tiwari - Journal of Biological Systems, 2023 - World Scientific
… After the introduction, we describe the biological background behind the formulation of the
… antigen representing cells (APCs) in vertebrate immune systems and, in our model, are the …

A multi-compartment hybrid computational model predicts key roles for dendritic cells in tuberculosis infection

S Marino, DE Kirschner - Computation, 2016 - mdpi.com
… computational modeling approach to … dendritic cells as they serve as the link between
physiological compartments of lungs and lymph nodes (LNs) that generate activated immune cells

Logical modeling of cell fate specification—Application to T cell commitment

E Cacace, S Collombet, D Thieffry - Current Topics in Developmental …, 2020 - Elsevier
cell differentiation, pattern formation and embryonic development. Here, we describe a logical
modeling … rules specifying the behavior of model components depending on the levels or …

Modeling Dendritic Cell Pulsed Immunotherapy for Mice with Melanoma—Protocols for Success and Recurrence

JC Chimal-Eguia, E Castillo-Montiel… - Applied Sciences, 2021 - mdpi.com
… The model and parameter are adjusted for the … The model consists of ODE system that
considers interactions between melanoma cells (T), cytotoxic T cells (CTLs), dendritic cells (…