TLR signalling and the function of dendritic cells
H Hemmi, S Akira - Mechanisms of epithelial defense, 2005 - karger.com
… of cells including macrophages (Ms) and dendritic cells (DCs). In addition, stimulation with
TLR ligands also … ability to naive T cells, resulting in effective activation of acquired immunity. …
TLR ligands also … ability to naive T cells, resulting in effective activation of acquired immunity. …
Targeted delivery of TLR ligands to human and mouse dendritic cells strongly enhances adjuvanticity
PJ Tacken, IS Zeelenberg, LJ Cruz… - Blood, The Journal …, 2011 - ashpublications.org
… to dendritic cells (DCs) improves vaccine efficacy, we report here that co-targeting of TLR
ligands (… We encapsulated ligands for intracellular TLRs within biodegradable nanoparticles …
ligands (… We encapsulated ligands for intracellular TLRs within biodegradable nanoparticles …
Toll‐like receptor ligand activation of murine bone marrow‐derived dendritic cells
RJ Dearman, M Cumberbatch, G Maxwell… - …, 2009 - Wiley Online Library
… Lipopolysaccharide (LPS) induces cytokine secretion by dendritic cells (DCs). … (TLR-grade)
TLR ligands on activation of day 6 DCs was examined. A range of doses of each TLR ligand …
TLR ligands on activation of day 6 DCs was examined. A range of doses of each TLR ligand …
TLR-mediated induction of negative regulatory ligands on dendritic cells
S Gröschel, KD Piggott, A Vaglio, W Ma-Krupa… - Journal of Molecular …, 2008 - Springer
… TLR4 ligands induces divergent T-cell proliferative responses To examine how conditioning
of DCs through different TLR ligands affects CD4 + T cells, … CD4 + T-cell proliferation. In vitro-…
of DCs through different TLR ligands affects CD4 + T cells, … CD4 + T-cell proliferation. In vitro-…
Toll-like receptors and dendritic cells: for whom the bug tolls
CR e Sousa - Seminars in immunology, 2004 - Elsevier
… with T cells, how different DC subsets respond to TLR ligands and how the … TLR ligands,
converting “immature DC” into “mature” cells that possess an increased ability to stimulate T cell …
converting “immature DC” into “mature” cells that possess an increased ability to stimulate T cell …
Regulation of dendritic cell function through Toll-like receptors
T Kaisho, S Akira - Current molecular medicine, 2003 - ingentaconnect.com
… cells and function as TLR ligands. For example, heat shock proteins (HSPs), released from
injured cells, can activate APCs through TLR2 or TLR4 [… acids require TLR4 for their immune …
injured cells, can activate APCs through TLR2 or TLR4 [… acids require TLR4 for their immune …
Toll-like receptor ligands synergize through distinct dendritic cell pathways to induce T cell responses: implications for vaccines
Q Zhu, C Egelston, A Vivekanandhan… - Proceedings of the …, 2008 - National Acad Sciences
… We found that when certain TLRs are involved, dendritic cells (DCs) establish unidirectional
… T cell response to a given vaccine in vivo. Therefore, our study revealed an underlying TLR …
… T cell response to a given vaccine in vivo. Therefore, our study revealed an underlying TLR …
Toll-like receptor ligands modulate dendritic cells to augment cytomegalovirus-and HIV-1-specific T cell responses
… To determine whether the functional enhancement of APCs by TLR ligands could augment
memory CMV-specific T cell function, we first evaluated the ability of enriched cultures of …
memory CMV-specific T cell function, we first evaluated the ability of enriched cultures of …
A subset of Toll-like receptor ligands induces cross-presentation by bone marrow-derived dendritic cells
SK Datta, V Redecke, KR Prilliman… - The Journal of …, 2003 - journals.aai.org
… (TLRs) leads to activation of DCs and subsequent orchestration of an adaptive immune
response. We hypothesized that microbial TLR ligands … microbial TLR ligands, namely ligands of …
response. We hypothesized that microbial TLR ligands … microbial TLR ligands, namely ligands of …
Dendritic cell function can be modulated through cooperative actions of TLR ligands and invariant NKT cells
… the cooperative actions of iNKT cells and TLR ligands, chicken OVA … TLR4 ligand MPL, the
iNKT cell ligand α-GalCer, or a combination of both, into wild-type and TLR4-deficient (TLR4 −…
iNKT cell ligand α-GalCer, or a combination of both, into wild-type and TLR4-deficient (TLR4 −…
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