… On the basis of our current findings, we propose that pathogen blockade of TAK1-IKK triggers
… Our observations suggest that the blockade of the TAK1-IKK pathways leads to cytotoxicity, …

… We and others recently demonstrated that RIPK1-dependent … , 37), we next investigated the
cleavage status of neutrophil … robust caspase-11–dependent GSDMD cleavage, as a positive …

… Global, general blockade of NF-κB signaling either by cleavage alone or in combination …
protease-mediated p65 cleavage, the RPS3-dependent selective inhibition mechanism could …

… in response to pathogens. Here we show that TLR9 proteolytic cleavage is a prerequisite
for … from the inhibitory effects of a broad protease blockade, with very few exceptions, it has …

… -dependent cleavage of VE-cadherin was accompanied by a similar event targeting one
major component of tight junctions, occludin. The cleavage … , and this cleavage has often been …

… dramatically less TNF because of YopJ-dependent inhibition of cell signaling, but … dependent
apoptosis during in vivo Yersinia infection have not been investigated. Staining for cleaved …

… Blockade of RIP3 kinase activity with GSK’872 strongly reduced … Cleavage and activation
of the downstream apoptotic … understanding of how bacterial pathogens, via their T3SS, can …

… Cleavage of CAM by sheddases results in the release of soluble forms of CAM. The … during
pathogenic microbial invasion, with a particular focus on bacterial-induced cleavage of E-cad. …

… Interestingly, Yersinia type III secretion system effector protein, YopJ, activates NLRP3 via
a novel mechanism; YopJ inhibits TAK1, which leads to a caspase-8-dependent cleavage of …

… is a RIPK-dependent lytic cell death that serves as a backup system to fully eliminate intracellular
pathogens when … Consistent with OspD3-dependent RIPK cleavage, the levels of MLKL …