… risk of pain chronification. A greater understanding of the role of descending pain modulation
can lead … directions aimed at normalizing aberrant processes that can lead to chronic pain. …

… descending modulation of pain perception has never been better. Here, a sharp focus on
the most relevant and recent articles published in the field shapes our current understanding of …

… This study describes an ascending–descending pain modulation pathway triggered by
pain and dependent on the NAc and on the PAG–RVM descending system. The ascending …

… However, the RVMM contains functionally heterogeneous groups of serotonergic and
nonserotonergic neurons that are not only involved in pain modulation but also in control of …

… of endogenous systems of pain modulation. Initial interest focused on descending inhibition
of spinal nociceptive processing, but we now know that descending modulation of spinal …

… also reflect changes in central pain modulating pathways. Hurley and Hammond (2000,
2001) have demonstrated enhancement and plasticity of the descending inhibitory effects of mu …

… descending modulatory system may become maladaptive and durably altered so that pain
… and instead points to an independent role of these facilitatory neurones in pain modulation. …

… modulation Little is understood regarding the spinal circuits through which descending pain
… Recent inroads into understanding the spinal substrate for descending antinociception have …

… abnormal pain modulation pathway focusing on disinhibition of the descending inhibitory pain
… summarize the evidences on alteration of this pathway in various chronic pain conditions. …

… The PAG-RVM system remains the best-studied circuit for descending pain modulation, and
… the engagement of descending pain-modulating systems via spinoparabrachial pathways. …