The design and synthesis of circular RNAs
P Obi, YG Chen - Methods, 2021 - Elsevier
… Circular RNAs (circRNAs) are a novel class of RNAs distinguished … synthesized circRNAs
for specific biological roles. We focus on the most common applications, including designing …
for specific biological roles. We focus on the most common applications, including designing …
Optimal design of synthetic circular RNAs
SW Choi, JW Nam - Experimental & Molecular Medicine, 2024 - nature.com
… circular RNAs and summarizes the available options for each step of exogenous circular RNA
design and synthesis… this review describes several potential applications of circular RNAs. …
design and synthesis… this review describes several potential applications of circular RNAs. …
Circular RNA: An emerging frontier in RNA therapeutic targets, RNA therapeutics, and mRNA vaccines
… Circular RNAs (circRNA) is a class of natural (biogenic) or synthetic closed RNA without 5′ …
(Adapted from Litke, JL and SR Jaffrey, Highly efficient expression of circular RNA aptamers …
(Adapted from Litke, JL and SR Jaffrey, Highly efficient expression of circular RNA aptamers …
Design and Synthesis of Circular RNA Expression Vectors
J Frei, NT Jarzebska, M Mellett, TM Kündig… - RNA Vaccines: Methods …, 2024 - Springer
… The increased interest in mRNA-based technologies has spurred a renaissance for circular
RNA (circRNA), as the lack of free 5′ and 3′ ends substantially increases resistance …
RNA (circRNA), as the lack of free 5′ and 3′ ends substantially increases resistance …
Characterizing and circumventing sequence restrictions for synthesis of circular RNA in vitro
JW Rausch, WF Heinz, MJ Payea… - Nucleic Acids …, 2021 - academic.oup.com
… in T4 td PIE construct design. Based on the results of our analysis, we present a set of
guidelines for designing PIE transcription templates for efficient synthesis of almost any circRNA, …
guidelines for designing PIE transcription templates for efficient synthesis of almost any circRNA, …
Circular RNAs as therapeutic agents and targets
LM Holdt, A Kohlmaier, D Teupser - Frontiers in physiology, 2018 - frontiersin.org
… It has recently been reported that thousands of covalently linked circular RNAs (circRNAs)
are … which designer functions could be engineered into artificial therapeutic circular RNAs. …
are … which designer functions could be engineered into artificial therapeutic circular RNAs. …
Synthesis and engineering of circular RNAs
S Petkovic, S Müller - Circular RNAs: Methods and Protocols, 2018 - Springer
… Here we describe the chemical synthesis of a small RNA (49 nts) site-specifically modified
with 5-fluorouridine followed by circularization with T4 RNA ligase I (Fig. 2A). Furthermore, we …
with 5-fluorouridine followed by circularization with T4 RNA ligase I (Fig. 2A). Furthermore, we …
Engineering circular RNA for enhanced protein production
… Circular RNAs (circRNAs) are stable and prevalent RNAs in eukaryotic cells that arise from
back-splicing. Synthetic circRNAs and some endogenous circRNAs can encode proteins, …
back-splicing. Synthetic circRNAs and some endogenous circRNAs can encode proteins, …
Chemical Synthesis of Circular RNAs with Phosphoramidate Linkages for Rolling‐Circle Translation
K Nakamoto, H Abe - Current Protocols, 2021 - Wiley Online Library
… of the circular RNAs … synthesis and purification of circular RNAs for rolling-circle translation
(Nakamoto et al., 2020). This approach enables a more practical synthesis of circular RNA …
(Nakamoto et al., 2020). This approach enables a more practical synthesis of circular RNA …
Circular RNA: Design Criteria for Optimal Therapeutical Utility
EM Carmona - 2019 - search.proquest.com
… Circular RNA extends protein expression longer than linear modified RNA in vivo ........... 69
… Since circular RNA is covalently linked at its 5’-3’ end it is resistance to RNase R digestion. (D…
… Since circular RNA is covalently linked at its 5’-3’ end it is resistance to RNase R digestion. (D…
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