Disruption of histone methylation in developing sperm impairs offspring health transgenerationally
… with altered histone methylation levels for genes in sperm. This … reduced histone methylation
during sperm development … , our study implicates histone methylation and sperm RNA as …
during sperm development … , our study implicates histone methylation and sperm RNA as …
[PDF][PDF] The sperm epigenome and potential implications for the developing embryo
TG Jenkins, DT Carrell - Reproduction, 2012 - researchgate.net
… regulatory competence via histone tail modifications. Indeed, recent studies have implicated
aberrant histone methylation and/or acetylation in the mature sperm in various forms of …
aberrant histone methylation and/or acetylation in the mature sperm in various forms of …
Repressive and active histone methylation mark distinct promoters in human and mouse spermatozoa
U Brykczynska, M Hisano, S Erkek, L Ramos… - Nature structural & …, 2010 - nature.com
… Histone methylation status in sperm versus somatic cells To relate genomic localization
to chromatin regulation during development, we compared ChIP patterns in sperm to those …
to chromatin regulation during development, we compared ChIP patterns in sperm to those …
[HTML][HTML] Epigenetic homogeneity in histone methylation underlies sperm programming for embryonic transcription
… We show that during spermiogenesis, the programming of sperm genes for embryonic
development is associated with the formation of chromatin regions of homogeneous epigenetic …
development is associated with the formation of chromatin regions of homogeneous epigenetic …
The human sperm epigenome and its potential role in embryonic development
DT Carrell, SS Hammoud - MHR: Basic science of reproductive …, 2009 - academic.oup.com
… To better understand the chromatin landscape at histone-… : histone variants, histone
modifications and DNA methylation. … in histone modifications, variants and/or DNA methylation …
modifications and DNA methylation. … in histone modifications, variants and/or DNA methylation …
Histone methylation regulates gene expression in the round spermatids to set the RNA payloads of sperm
… development, and germ cell development, which strongly support the idea that the genes
participating in sperm … genes showed their roles in sperm development, sperm flagellum, 9 + 2 …
participating in sperm … genes showed their roles in sperm development, sperm flagellum, 9 + 2 …
Heterogeneous distribution of histone methylation in mature human sperm
FA La Spina, M Romanato, S Brugo-Olmedo… - Journal of assisted …, 2014 - Springer
… histone methylation in normal mature human sperm. We observed that 12 to 30 % of the nuclei
of normal sperm … and post-translational modifications on fertility and embryo development. …
of normal sperm … and post-translational modifications on fertility and embryo development. …
[HTML][HTML] Emerging evidence that the mammalian sperm epigenome serves as a template for embryo development
… Finally, although over 70% of the sperm epigenome is in a methylated state, DNA methylation
remains mostly devoid at CpG dense promoters bearing nucleosomes. Panel created with …
remains mostly devoid at CpG dense promoters bearing nucleosomes. Panel created with …
Distinctive chromatin in human sperm packages genes for embryo development
SS Hammoud, DA Nix, H Zhang, J Purwar, DT Carrell… - Nature, 2009 - nature.com
… enriched at imprinted gene clusters, and a notable correlation between H3K4me3 and
paternally expressed noncoding RNAs and genes; loci that lack DNA methylation in sperm. In …
paternally expressed noncoding RNAs and genes; loci that lack DNA methylation in sperm. In …
Genes for embryo development are packaged in blocks of multivalent chromatin in zebrafish sperm
… sperm genome packaged in nucleosomes and histone variants (and not protamine), and we
find linker histones … methylation in development, we compared DNA methylation profiles in …
find linker histones … methylation in development, we compared DNA methylation profiles in …
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