… in aging has yet to be elucidated. This review addresses this issue and investigates the
role of DNA methylation and its mechanisms in aging, age-related disease, and rejuvenation. …

… evidence of genome-wide DNA methylation alterations in aging and age-related disease.
It is currently well established that DNA methylation biomarkers can determine biological age …

… DNA methylation do not distinguish between them, and so for the purposes of this review, all
such modifications to DNA will be referred to as ‘DNA methylation… between DNA methylation …

… methylation status of specific genes with aging, their impact on diseases that develop with
aging, and mechanisms that may contribute to the altered DNA methylation patterns. As this …

… embryonic development, (Li et al., 1992; Okano et al., 1999). Our understanding of DNA
methylation has evolved from one in which methylation patterns are set during development and …

… DNA methylation is strongly associated with genotypic variants and correlates with …
development and in de novo DNA methylation. Our results indicate that promoter DNA methylation in …

… D and DNA methylation in candidate disease … D on DNA methylation. In light of current
knowledge in the field, the potential mechanisms mediating vitamin D effects on DNA methylation …

… DNA methylation changes during healthy aging and disease: (i) in the case of (A) or (B), both
aging and disease-related DNA methylation … DNA methylation underlies the development …

… DNA methylation in vascular aging-related diseases and represent many vascular disease-related
genes that are regulated by DNA methylation… prospect of DNA methylation as an early …

… tions and hypotheses regarding epigenetic modifications in normal aging and age-related
diseases in humans, with an emphasis on DNA methylation and its role in the aging process. …