… the observed epigenetic changes are … development of curcumin has been limited by the
poor pharmacokinetic profile and low potency [12]. Our group has developed over 100 curcumin …

… Epigenetic modifiers are agents that modulate the epigenetic landscape and … epigenetic
modifiers were developed originally for the treatment of cancer, the utility of these agents in …

… Chronic inflammation is a key driver of cancer development. Nitrite levels, which are …
The role of curcumin as an anti-inflammatory agent and its ability to inhibit the expression of …

… The role of epigenetics in the development of diseases was … between curcumin and DNMT1
showed that curcumin produces … show that curcumin is a potent DNA hypomethylating agent, …

… of epigenetics and gene transcriptional regulation creates a suitable microenvironment for
cancer development… EGCG, curcumin, resveratrol, and genisten as anticancer agents are poor …

… With our increased understanding of the molecular and epigenetic/epigenomic changes
during CRC development, we will be able to develop new and more precise therapies, …

… of potential epigenetic mechanisms of curcumin in reversing altered … such as curcumin to
evade the development of resistance … of curcumin as an epigenetic anti-cancer agent are new …

… Epigenetic regulation … Epigenetic silencing of genes through CpG island hypermethylation
has been accepted as an important potential carcinogenic mechanism in the development of …

… was shown to act at different stages of cancer development, … Finally, curcumin modulates
the epigenetic landscape by … , especially when curcumin is used as a protective agent. As we …

… The development of natural compounds is attracting more and more attention as … nutraceutical
agents like Curcumin would be an appealing strategy to enhance the epigenetic efficiency …