… Curcumin's role in attenuating the development of Aβ plaques in the brain and promoting …
Pharmacodynamics of curcumin as DNA hypomethylation agent in restoring the expression …

… Curcumin can act as a DNA hypomethylation agent and this … epigenetic regulation, such as
promoter hypermethylation [Citation17,Citation18]. Therefore, we hypothesized that curcumin …

… and development. In addition, remarkable advances in our understanding of basic … The
agents which we discuss include tea polyphenol–catechins (green tea), curcumin (turmeric), …

… Interestingly, when used as a single agent, the effects of the STACs were independent of
TP53 gene status. However, when either SRT1720 or RES were added in combination with a …

… leading the way in the development of agents that target epigenetic pathways at levels of …
of curcumin have been extensively studied. Curcumin and derivatives are epigenetically active …

… curcumin inhibits the binding of p65 to TREM-1 promoter in response to LPS. Further we
show that curcumin … Since curcumin is a potent anti-inflammatory agent, we hypothesized that …

… in the field of HDACi development, which remains unanswered, is whether selective
inhibition of HDACs would be advantageous over broader-acting HDACi as anti-cancer agents. …

… Moreover, curcumin also modulates gene expression through its activity as an epigenetic
agent. In particular, curcumin induces DNA hypomethylation through inhibition of DNMT1, as …

… Till date numerous research has been conducted to understand the epigenetic mechanisms…
the development of various cancer types [91]. Curcumin regulates epigenetic modification …

… Epigenetic modulation by curcumin has been demonstrated … of curcumin, curcumin glucuronide
and curcumin sulfate, are … have been developed to optimize bioavailability of curcumin. …