Curcumin sensitizes pancreatic cancer cells to gemcitabine by attenuating PRC2 subunit EZH2, and the lncRNA PVT1 expression

K Yoshida, S Toden, P Ravindranathan, H Han… - …, 2017 - academic.oup.com
… ), is a histone methyltransferase that epigenetically maintains CSCs by regulating gene …
curcumin could result in the development of safer and more potent chemotherapeutic agents

[HTML][HTML] Effect of curcumin in comparison with trichostatin A on the reactivation of estrogen receptor alpha gene expression, cell growth inhibition and apoptosis …

M Sanaei, F Kavoosi, M Arabloo - Asian Pacific journal of cancer …, 2020 - ncbi.nlm.nih.gov
agents and histone deacetylase inhibitors on HCC and colon cancer. This study aimed to
evaluate the effect of curcumin (… genetic and epigenetic alterations, epigenetic processes such …

[HTML][HTML] Curcumin induces re-expression of BRCA1 and suppression of γ synuclein by modulating DNA promoter methylation in breast cancer cell lines

N Al-Yousef, Z Shinwari, B Al-Shahrani… - Oncology …, 2020 - spandidos-publications.com
… is linked with a high risk of developing breast and ovarian cancer. … effect of curcumin to that
of the demethylating agent 5′-aza-… The fact that curcumin exerts an effect on both epigenetic

[HTML][HTML] The role of curcumin in cancer treatment

V Zoi, V Galani, GD Lianos, S Voulgaris, AP Kyritsis… - Biomedicines, 2021 - mdpi.com
agents. It affects several signaling pathways and can thus effectively modify both the
development and the … regulation of genes by regulating the expression of epigenetic markers [69]. …

Modulation of epigenetic methylation enzymes by synthetic and natural agents

MK Shanmugam, CD Mohan, KS Rangappa… - … and Translation in …, 2023 - Elsevier
… Therefore, the epigenetic activity of curcumin has proved that … Curcumin has also been
shown to suppress EZH2 … of deregulated epigenetic regulatory processes in the development of …

… prevents apoptosis and improves motor deficits in park 7 (DJ-1)-knockout rat model of Parkinson's disease: implications for epigenetics-based nanotechnology-driven …

S Chiu, KJ Terpstra, Y Bureau, J Hou… - … of Complementary and …, 2013 - degruyter.com
… bioavailability for developing CNS … for curcumin have been tested in genetic models of PD.
We have previously shown that liposome-based curcumin formulation, Lipocurc™ developed

Health-promoting role of dietary bioactive compounds through epigenetic modulations: a novel prophylactic and therapeutic approach

A Kumari, S Bhawal, S Kapila, H Yadav… - Critical Reviews in …, 2022 - Taylor & Francis
… for normal development and functioning of an individual. … Curcumin is known to be a HAT
inhibitor and play an … by acting prophylactic and therapeutic agents but our knowledge about …

Curcumin analogue CDF inhibits pancreatic tumor growth by switching on suppressor microRNAs and attenuating EZH2 expression

B Bao, S Ali, S Banerjee, Z Wang, F Logna, AS Azmi… - Cancer research, 2012 - AACR
… The histone methyltransferase EZH2 is a central epigenetic … been found to be associated
with the development of cancers (8). … and a known natural antitumor agent, on cell survival, …

[HTML][HTML] Curcumin: a promising tool to develop preventive and therapeutic strategies against non-communicable diseases, still requiring verification by sound clinical …

R Masella, F Cirulli - Nutrients, 2022 - mdpi.com
… Natural antioxidant agents such as curcumin have pleiotropic … [8] review evidence for
curcumin to modulate epigenetic … the potential epigenetic mechanisms of curcumin in reversing …

[HTML][HTML] Curcumin‑induced promoter hypermethylation of the mammalian target of rapamycin gene in multiple myeloma cells

J Chen, Y Ying, H Zhu, T Zhu, C Qu… - Oncology …, 2019 - spandidos-publications.com
… As a potential cancer inhibitor, curcumin inhibits almost every phase of tumor development,
… role in epigenetic regulation remains unknown. In the present study, curcumin was revealed …