Viral infection and aging as cofactors for the development of pulmonary fibrosis

PK Naik, BB Moore - Expert review of respiratory medicine, 2010 - Taylor & Francis
… We were successful in modeling a rapid exacerbation of pulmonary fibrosis using MHV-68
infection in mice with already established pulmonary fibrosis. Mice with established FITC-…

Development of pulmonary fibrosis through a pathway involving the transcription factor Fra-2/AP-1

R Eferl, P Hasselblatt, M Rath… - Proceedings of the …, 2008 - National Acad Sciences
pulmonary fibrosis. These findings indicate that Fra-2 expression is sufficient to cause pulmonary
fibrosis in … considered a contributing pathogenic factor of pulmonary fibrosis in humans. …

Serial development of pulmonary hypertension in patients with idiopathic pulmonary fibrosis

SD Nathan, OA Shlobin, S Ahmad, J Koch, SD Barnett… - Respiration, 2008 - karger.com
… Background: Idiopathic pulmonary fibrosis (IPF) is a disease with very high mortality.
Objective: We sought to characterize serial changes in pulmonary artery pressures (PAP) in …

[HTML][HTML] Challenges for clinical drug development in pulmonary fibrosis

ES White, M Thomas, S Stowasser… - Frontiers in …, 2022 - frontiersin.org
pulmonary fibrosis that leads to respiratory failure and death. Idiopathic pulmonary fibrosis
(… of progressive fibrosing ILD, and the development of pirfenidone and nintedanib has been a …

[HTML][HTML] Pulmonary fibrosis: pathogenesis, etiology and regulation

MS Wilson, TA Wynn - Mucosal immunology, 2009 - Elsevier
pulmonary fibrotic conditions, idiopathic pulmonary fibrosis (IPF), is still unclear. This review
examines common mechanisms of pulmonary … most widespread pulmonary fibrotic diseases…

Idiopathic pulmonary fibrosis: Disease mechanisms and drug development

P Spagnolo, JA Kropski, MG Jones, JS Lee… - Pharmacology & …, 2021 - Elsevier
… The importance of dysregulation of alveolar epithelial cells in the initiation of pulmonary
fibrosis has been strengthened by the recent observation that an IPF-associated mutation in the …

[HTML][HTML] Essential roles of the Fas-Fas ligand pathway in the development of pulmonary fibrosis

K Kuwano, N Hagimoto, M Kawasaki… - The Journal of …, 1999 - Am Soc Clin Investig
… To investigate the role of Fas-FasL interaction in the development of bleomycin-induced
pulmonary fibrosis, we used hFas-Fc in which the extracellular region of human Fas is fused to …

Differential Expression of VEGF-Axxx Isoforms Is Critical for Development of Pulmonary Fibrosis

SL Barratt, T Blythe, C Jarrett, K Ourradi… - American journal of …, 2017 - atsjournals.org
pulmonary fibrosis, ATII-specific deficiency of VEGF-A or constitutive overexpression of VEGF-A
165 b inhibited the development of pulmonary fibrosisdevelopment of pulmonary fibrosis

[HTML][HTML] Prediction of the development of pulmonary fibrosis using serial thin-section CT and clinical features in patients discharged after treatment for COVID-19 …

M Yu, Y Liu, D Xu, R Zhang, L Lan… - Korean journal of …, 2020 - ncbi.nlm.nih.gov
… However it has rarely been reported whether discharged patients develop fibrosis, … pulmonary
fibrosis. In this study, we aimed to identify predictors for development of pulmonary fibrosis

[HTML][HTML] Pulmonary fibrosis: patterns and perpetrators

PW Noble, CE Barkauskas… - The Journal of clinical …, 2012 - Am Soc Clin Investig
… This type of pulmonary fibrosis has not been investigated rigorously, and this … of pulmonary
fibrosis. Thus, the ability to distinguish IPF and UIP from other forms of pulmonary fibrosis is of …