… :* Clinical aspects of Huntington's disease, including … aspects, and new chapters on juvenile
Huntington's and the premanifest and early stages* The genetics of Huntington's disease, …

Huntington's disease is an autosomal-dominant, progressive neurodegenerative disorder
with a distinct phenotype, including chorea and dystonia, incoordination, cognitive decline, …

… In this Review, we focus on current clinical, neuroimaging, and biochemical biomarker
development for Huntington's disease and its implications for future clinical research. …

… the developmental aspects of human diseases. Using isogenic Huntington’s disease human
… arise in our model of early human development as a consequence of mutant huntingtin …

… network development and then discuss recent evidence for its alterations in rodent models
of the disease. We argue that a better understanding of the striatum's development should …

… This article presents a general update on Huntington's disease (HD) and reviews the …
Finally, the future of HD holds promise for the development of rational, neurobiologically-based …

… The importance of psychiatric aspects of HD has been recognized since the time of Huntington.
In his original description of the disease Huntington (1872) wrote that ‘... In all the families…

… Our findings may also have implications for juvenile Huntington's disease (JHD), where
this developmental component may play a key role. Individuals with JHD usually exhibit very …

… The nature of the alternative HTT exon1 conformations triggered by polyQ expansion that
are responsible for development of Huntington disease continues to be debated. Given the …

… a vital gene for brain development. mHTT is expressed throughout life and could conceivably
have deleterious effects on brain development. The end event in the disease is, of course, …