… We found that USP9X and ZC4H2 had a genome-wide significant excess of DNMs in female
probands, indicating these genes have X-linked dominant modes of inheritance in addition …

… We observed no significant excess of any functional class of … As many of our candidate
developmental disorder genes … function phenotypes in zebrafish may exceed that observed in our …

… test to identify chromosomes with a significant burden of uniparentally … Developmental
Disorders project, a trio-based rare disease study, and detected six validated events, a significant …

… The PDD-NOS group showed results similar to those of the autism group, with significantly
… A prolonged labor may be caused by fetal malposition, fetopelvic disproportion, excess …

… surveys of autism, the attributable proportion of cases of autism would not exceed the 10%
figure for any medical disorder (excluding epilepsy and sensory impairments). Although this …

… were significantly associated with developmental disorders, … developmental disorders.
Although we detected more genes associated with developmental disorders, much of the excess …

… 24 genes with a significant excess of de novo missense … significance (for example, SCN2A,
STXBP1, CHD2, and CASK), whereas others were significant only on the basis of an excess …

… ) together, we observed no statistically significant difference in the overall burden within …
For the 1,575 probands with a diagnosis of 'autism' or 'pervasive developmental disorder' (…

… Psychological research has helped to develop new developmental models for the disorder
and there have also been significant advances in the molecular genetics of autism and …

… After adjusting for cofounders, these excess mortality risks remain significant and are of
similar magnitude. To demonstrate how excess mortality varied by gender, we reanalyzed the …