… on general principles of developmental changes in absorption, distribution, metabolism and
elimination of medications throughout infancy, childhood and adolescence. In addition the …

… The goal of developmental pharmacology is to have sufficient evidence about … developmental
pharmacology can be combined with drug information to justify recruitment of adolescents (…

… , neonates, infants, and adolescents) are frequently necessary … and children undergo
significant developmental changes in … I examine relevant changes in pediatric pharmacology and …

… of development that defines the essential differences between children and adults. A basic
understanding of the developmental dynamics in pediatric pharmacology … and development. …

… of brain development during childhood and adolescence is key to … The number of
children and adolescents who are … In addition, correlation to pharmacological therapy …

… is significantly higher in adolescents than in adults.Because both the parent drug and its
metabolites contribute to the pharmacologic effect, adolescents may not need higher doses. …

… present numerous pharmacological conundrums for the anaesthetist. Extensive changes
in drug absorption, protein binding, metabolism and excretion during development result in …

Recognition of the need for alternative analgesic regimens for managing neonatal and
childhood pain has led to a rich literature concerning the ways in which early life pain differs from …

… Furthermore, when present, developmental toxicokinetic differences ultimately must be
linked to clinically relevant disease endpoints. Developmental pharmacology data provide a …

… It is not known if tissue binding is related to pharmacological effect of drugs [24]. The
relationship between apparent volume of distribution, drug binding, and plasma volume can be …