Fatty acids, obesity, and insulin resistance: time for a reevaluation

F Karpe, JR Dickmann, KN Frayn - Diabetes, 2011 - Am Diabetes Assoc
… process of fatty acid mobilization from … “fatty acids as metabolic villains,” together with data
from the literature and from our own studies, which tend to show another side to the fatty acids/…

Fatty acid metabolism in obesity and type 2 diabetes mellitus

EE Blaak - Proceedings of the Nutrition Society, 2003 - cambridge.org
… to oxidise fatty acids. A dysbalance between fatty acid uptake and fatty acid oxidation may
in … in pathways of lipolysis and skeletal muscle fatty acid handling, and discusses underlying …

Regulation of hepatic fatty acid elongase and desaturase expression in diabetes and obesity

Y Wang, D Botolin, J Xu, B Christian, E Mitchell… - Journal of lipid …, 2006 - ASBMB
fatty acid structure, physiological control of fatty acid elongation remains poorly defined. The
predominant pathway for fatty acid … and uses malonyl-CoA and fatty acyl-CoA as substrates …

Free fatty acids in obesity and type 2 diabetes: defining their role in the development of insulin resistance and β‐cell dysfunction

G Boden, GI Shulman - European journal of clinical …, 2002 - Wiley Online Library
… Influence of body fat distribution on free fatty acid metabolism in obesity. J Clin Invest 1989;…
fatty acids lowers basal insulin secretion in diabetic and nondiabetic subjects. Diabetes 1998;…

Fatty acid-induced β cell apoptosis: a link between obesity and diabetes

M Shimabukuro, YT Zhou, M Levi… - Proceedings of the …, 1998 - National Acad Sciences
… demonstrated in islets of obese ZDF rats a pathway of lipotoxicity leading to diabetes. Elevated
levels of circulating FFA (4) and lipoproteins transport to islets of obese ZDF rats far more …

N-3 long chain polyunsaturated fatty acids: a nutritional tool to prevent insulin resistance associated to type 2 diabetes and obesity?

J Delarue, C LeFoll, C Corporeau… - Reproduction nutrition …, 2004 - rnd.edpsciences.org
… Patients with obesity or type 2 diabetes are characterized by a different fatty acid composition
of serum lipids as compared to healthy lean subjects [27]. This abnormal fatty acid profile is …

[PDF][PDF] Molecular therapy for obesity and diabetes based on a long‐term increase in hepatic fattyacid oxidation

JM Orellana‐Gavaldà, L Herrero, MI Malandrino… - …, 2011 - Wiley Online Library
… the notion that increased flux of fatty acids exclusively … as a consequence of increased hepatic
fatty acid flux through mitochondria. … However, increased fatty acid flux in the absence of a …

The role of free fatty acid metabolism in the pathogenesis of insulin resistance in obesity and noninsulin-dependent diabetes mellitus

LC Groop, C Saloranta, M Shank… - The Journal of …, 1991 - academic.oup.com
… of insulin resistance in obesity and noninsulin-dependent diabetes mellitus (NIDDM), we …
pathways of free fatty acid (FFA) and glucose metabolism in 14 lean and 17 obese (with normal …

Obesity and free fatty acids

G Boden - Endocrinology and metabolism clinics of North America, 2008 - Elsevier
… Chronically elevated plasma FFA levels, as commonly seen in obese diabetic and
nondiabetic individuals, also cause insulin resistance. This relationship was demonstrated by …

Effects of short chain fatty acid producing bacteria on epigenetic regulation of FFAR3 in type 2 diabetes and obesity

M Remely, E Aumueller, C Merold, S Dworzak, B Hippe… - Gene, 2014 - Elsevier
… chain fatty acidsfatty acid receptor) and other short chain fatty acid receptors. We studied
a potential interaction of the microbiota with epigenetic regulation in obese and type 2 diabetes