DPP4 in diabetes

D Röhrborn, N Wronkowitz, J Eckel - Frontiers in immunology, 2015 - frontiersin.org
… of human islets suggesting that DPP4 is released from human … DPP4 activity. The contrary
was found in human islets from type 2 diabetic donors, showing a decreased DPP4 activity (…

The role of DPP4 activity in cardiovascular districts: in vivo and in vitro evidence

L Pala, CM Rotella - Journal of diabetes research, 2013 - Wiley Online Library
… a significant increase in DPP4 activity in type 1 and type 2 diabetes. This phenomenon …
hyperglycaemia in type 2 diabetic patients with poor metabolic control [10]. DPP4 is considered a …

Significance of circulatory DPP4 activity in metabolic diseases

T Nargis, P Chakrabarti - IUBMB life, 2018 - Wiley Online Library
… of RA in patients with T2DM treated with DPP4 inhibitor … DPP4 activity particularly in first
half of pregnancy 20 is not known. Plasma DPP4 levels are not different in gestational diabetes

Association of plasma DPP4 activity with mild cognitive impairment in elderly patients with type 2 diabetes: results from the GDMD study in China

T Zheng, L Qin, B Chen, X Hu, X Zhang, Y Liu… - Diabetes …, 2016 - Am Diabetes Assoc
DPP4 activities are independently associated with MCI in elderly patients with type 2
diabetes… The mechanisms might be partly explained by the effect of DPP4 on inflammation and …

Hyperglycaemia increases dipeptidyl peptidase IV activity in diabetes mellitus

E Mannucci, L Pala, S Ciani, G Bardini, A Pezzatini… - Diabetologia, 2005 - Springer
… dipeptidyl peptidase IV (DPP-IV) activity in endothelial cells in vitro… DPP-IV activity in patients
with type 1 and type 2 diabetes. … assessed DPP-IV activity in 31 type 2 diabetic patients with …

CD26/DPP4 levels in peripheral blood and T cells in patients with type 2 diabetes mellitus

SA Lee, YR Kim, EJ Yang, EJ Kwon… - The Journal of …, 2013 - academic.oup.com
… level, and serum DPP4 activity in patients with T2DM in … CD26/DPP4-related parameters
of T2DM patients with those … CD26/DPP4 activity in healthy subjects and patients with T2DM. …

Greater circulating DPP4 activity is associated with impaired flow-mediated dilatation in adults with type 2 diabetes mellitus

I Barchetta, G Ciccarelli, E Barone, FA Cimini… - Nutrition, Metabolism …, 2019 - Elsevier
… The relationship between DPP4 activity and endothelial function in diabetes has not been
… plasma DPP4 activity in relation to endothelial function in patients with type 2 diabetes

DPP-4 inhibitors in the treatment of type 2 diabetes

H Duez, B Cariou, B Staels - Biochemical pharmacology, 2012 - Elsevier
… Single doses of sitagliptin markedly and dose-dependently inhibited plasma DPP-4 activity,
… In this study, plasma DPP-4 activity was inhibited by more than 80% over 24 h at 50 mg and …

Increased plasma DPP4 activity is predictive of prediabetes and type 2 diabetes onset in Chinese over a four-year period: result from the China National Diabetes and …

T Zheng, Y Gao, A Baskota, T Chen… - The Journal of …, 2014 - academic.oup.com
… with the development of insulin resistance and type 2 diabetes. The aim of the present work
was to determine whether DPP4 activity and active GLP-1 could predict an increased risk of …

Plasma levels of DPP4 activity and sDPP4 are dissociated from inflammation in mice and humans

LL Baggio, EM Varin, JA Koehler, X Cao… - Nature …, 2020 - nature.com
… Here we examine whether reduction of DPP4 activity alters inflammation. Prolonged DPP4
inhibition … inhibitors are now widely used for the treatment of type 2 diabetes (T2D) 6 . …