… , islet inflammation has emerged as a contributor to the loss of functional β cell mass in both
type 1 (T1D) and type 2 diabetes (… our understanding of islet inflammatory pathways and to …

… and restorative functions of inflammatory factors and immune … of islet inflammation in diabetes
and models of prediabetes. We separately emphasize what is known on islet inflammation …

… -inflammatory cytokines, which cause the damage of pancreatic islet cells and, in type 2
diabetes, … That process results in the disturbed balance between pro-inflammatory and protective …

… that targeting islet inflammation has the … islet inflammation develops and causes β cell
dysfunction. We also emphasize the regulation and roles of macrophage polarity shift within islets …

… islet inflammation, the number of CD45 + leucocytes was higher within type 2 diabetic islets
… (as assessed by perifusion experiments) as compared with dysfunctional diabetic islets [26]. …

… Inflammation has … to inflammatory mediators, reactive oxygen species, and complement
components. In this review, we propose to revisit the pathology of islet failure in type 2 diabetes …

… models, increased islet IL-1β expression and increased numbers of islet … islet inflammatory
process in the GK rat, showing increased islet expression of IL-1β and other pro-inflammatory …

… , islet inflammation and increased IL-1β levels contribute to loss of β-cell function and mass
in T2D. IL-1β production in islets … diabetic states of T2D as well as in the metabolic syndrome. …

… , which may be important in initiating or maintaining the inflammatory response and
destruction of the β cell associated with autoimmune diabetes. [PSEBM 1996, Vol 211] …

… role in islet function and that cytokines are deleterious for -cells, we suggest that endothelial-islet
inflammation … This hypothesis is supported by the fact that treatments that preserve islet …