Changes in N6-methyladenosine modification modulate diabetic cardiomyopathy by reducing myocardial fibrosis and myocyte hypertrophy

W Ju, K Liu, S Ouyang, Z Liu, F He… - Frontiers in Cell and …, 2021 - frontiersin.org
… global RNA N6-methyladenosine (m 6 A) modification patterns in a mouse model of diabetic
cardiomyopathy (DCM). Patterns of m 6 A in DCM and normal hearts were analyzed via m 6

N6-Methyladenosine-mediated phase separation suppresses NOTCH1 expression and promotes mitochondrial fission in diabetic cardiac fibrosis

ZY Liu, LC Lin, ZY Liu, K Song, B Tu, H Sun… - Cardiovascular …, 2024 - Springer
… NOTCH1 was reconstituted in ALKBH5- and YTHDF2-deficient cardiac fibroblasts and …
and diabetic cardiac fibrosis. Heart tissue samples from patients with diabetic cardiomyopathy

N6-Adenosine Methylation (m6A) RNA Modification: an Emerging Role in Cardiovascular Diseases

Y Chen, X Ouyang, X Yu, P Novák, L Zhou… - Journal of …, 2021 - Springer
N6-methyladenosine (m 6 A) is the most abundant and … However, the exact roles of m 6
A in cardiovascular diseases (… m 6 A methylation in the progress of CVDs, such as cardiac

[HTML][HTML] N6-Methyladenosine in vascular aging and related diseases: clinical perspectives

C Li, L Liu, S Li, YS Liu - Aging and Disease, 2024 - pmc.ncbi.nlm.nih.gov
… N 6 -methyladenosine (m 6 A) is the most prevalent modification in eukaryotic RNAs. This
reversible m 6 A RNA modification is dynamically regulated by writers, erasers, and readers, …

METTL14 suppresses pyroptosis and diabetic cardiomyopathy by downregulating TINCR lncRNA

L Meng, H Lin, X Huang, J Weng, F Peng, S Wu - Cell death & disease, 2022 - nature.com
N6-methyladenosine (m6A) is one of the most important epigenetic regulation of RNAs, …
However, the underlying regulatory mechanism of m6A in diabetic cardiomyopathy (DCM) is …

[HTML][HTML] Unravelling the Impact of RNA Methylation Genetic and Epigenetic Machinery in the Treatment of Cardiomyopathy

L Liu, L Yu, Y Wang, L Zhou, Y Liu, X Pan… - Pharmacological …, 2024 - Elsevier
N6-methyladenosine (m6A), 5-methylcytosine (m5C), N7-methylguanosine (m7G), N1-methyladenosine
(m1A), 2'-O-methylation (Nm), and 6,2'-… In the context of diabetic cardiac fibrosis, …

LncRNA Airn alleviates diabetic cardiac fibrosis by inhibiting activation of cardiac fibroblasts via a m6A-IMP2-p53 axis

T Peng, M Liu, L Hu, D Guo, D Wang, B Qi, G Ren… - Biology Direct, 2022 - Springer
… dysfunction in patients with diabetes. However, the underlying mechanisms of cardiac
fibrosis … of cardiac fibrosis in diabetic cardiomyopathy (DCM) and its underlying mechanism. …

Regulation of N6-methyladenosine after myocardial infarction

M Vausort, M Niedolistek, AI Lumley, M Oknińska… - Cells, 2022 - mdpi.com
… The functional association between the regulation of m6A levels in blood and cardiac
dysfunction remains to be established, yet our data showing a positive correlation with cardiac

N6-methyladenosine RNA methylation in cardiovascular diseases

C Liu, L Gu, W Deng, Q Meng, N Li, G Dai… - Frontiers in …, 2022 - frontiersin.org
N6-methyladenosine (m6A) modification is the most universal and abundant post-transcriptional
modification of eukaryotic RNA and occurs mainly at the consensus motif RR (m6A) CH (…

[HTML][HTML] N 6methyladenine profiling of low‐input multiplex clinical samples on transcriptome reveals RNA modifications implicated in type 2 diabetes and acute …

S Qin, K Yang, S Han, Y Yuan, J Mo… - Clinical and …, 2023 - ncbi.nlm.nih.gov
Dear Editor, RNA N6-methyladenines (m6A) not only play an essential role in normal biological
processes but also participate in the pathogenesis of diseases including type 2 diabetes