… pathways within the cardiomyocytes which impair cardiac contractility and promote myocyte
dysfunction, injury and cell death. The exact mechanism of DCP pathogenesis is still unclear…

… In this study we examined the ability of CR to alleviate diabetic cardiomyopathy and to
identify the key pathways involved in CR mediated cardioprotection. CR is consider to be …

… that Sirt1-Foxo1 and PI3K-Akt pathways are involved … Sirt1-Foxo1 pathway and PI3K-Akt
survival pathway, blocks Foxo1 accumulation and eliminates ROS levels. In untreated diabetic …

… PERK/eIF2α, ATF6/CHOP, and IRE1α/JNK-mediated pathways. This study may provide
insights into a novel underlying mechanism and a strategy for treating diabetic cardiomyopathy. …

… the SIRT1 signaling pathway in diabetic cardiomyopathy. (a) Representative blots of SIRT1,
… (b–d) Histogram shows the quantitative expression changes of SIRT1, Ac-SOD2, and SOD2; …

… its target gene Sirt1 and alleviate diabetic cardiomyopathy OS via upregulating Sirt1 in vivo
… OS and apoptosis by activating Sirt1-Nrf2 signaling pathway, effectively improve myocardial …

… To demonstrate the signaling pathway of SIRT1 in mitochondrial regulation, we detected
acetylated protein in the six groups to reveal the level of acetylated PGC-1α (about 105 kDa, …

… Regulation of diabetic cardiomyopathy by caloric restriction is mediated by intracellular
signaling pathways involving ‘SIRT1 and PGC1a’. Cardiovasc Diabetol 2018; 17: 111. doi: …

… Besides, further studies targeting other related pathways such as AMPK, a major inducer
of SIRT1 are highly recommended. Also, searching further mechanisms that can be activated …

… on the Sirt1-FOXO1 and PI3K/AKT pathways (42). … pathway by 25-OH-PPD (43); and by the
inhibition of cardiac apoptosis, secondary to the activation of the PI3K/AKT/FOXO3a pathway …