Tiny molecule, big power: multi-target approach for curcumin in diabetic cardiomyopathy

V Karuppagounder, S Arumugam, VV Giridharan… - Nutrition, 2017 - Elsevier
… of diabetes, cardiovascular complications are considered to contribute largely to the death
rate of diabetes because of diabetic cardiomyopathy (DCM), sudden cardiac death, and …

Molecular mechanism of diabetic cardiomyopathy and modulation of microRNA function by synthetic oligonucleotides

N Ghosh, R Katare - Cardiovascular diabetology, 2018 - Springer
… non-ischemic heart failure associated with diabetes termed as diabetic cardiomyopathy (DCM…
Further, therapeutic modulation of miRs has gained some interest in diabetic heart disease

Exploring the complex relationship between diabetes and cardiovascular complications: understanding diabetic cardiomyopathy and promising therapies

N Ghosh, L Chacko, H Bhattacharya, J Vallamkondu… - Biomedicines, 2023 - mdpi.com
molecular and metabolic pathways underlying cardiac … , which may progress to heart
failure. It also highlights several … These tiny, noncoding RNA molecules play a critical role in …

Targeting miRNA for therapy of juvenile and adult diabetic cardiomyopathy

SS Nandi, PK Mishra - Exosomes, Stem Cells and MicroRNA: Aging …, 2018 - Springer
… of tiny non-coding regulatory RNAs, are differentially expressed in the diabetic heart and they
contribute to diabetic cardiomyopathymolecular mechanisms by which miRNA ameliorates …

MicroRNOmics of diabetic cardiomyopathy

PK Mishra, SC Tyagi - … Cardiomyopathy: Biochemical and Molecular …, 2014 - Springer
… of noncoding, conserved, tiny (19–24 nt) … diabetes and cardiovascular diseases because
each miRNA has several targets that allows it to make a layer of regulatory network. Diabetes is …

CaMKII signaling in heart diseases: emerging role in diabetic cardiomyopathy

B Hegyi, DM Bers, J Bossuyt - Journal of Molecular and Cellular Cardiology, 2019 - Elsevier
… II (CaMKII) is upregulated in diabetes and significantly contributes to cardiac remodeling with
increased risk of cardiac arrhythmias. Diabetes is frequently associated with atrial fibrillation…

Streptozotocin-induced type 1 and 2 diabetes mellitus mouse models show different functional, cellular and molecular patterns of diabetic cardiomyopathy

F Marino, N Salerno, M Scalise, L Salerno… - … journal of molecular …, 2023 - mdpi.com
… per se, a cardiomyopathy that leads to heart failure [8]. Diabetic cardiomyopathy is the focus
of active basic and clinical medicine to understand the cellular and molecular basis of DM …

Diabetic cardiomyopathy: Clinical phenotype and practice

X Zhao, S Liu, X Wang, Y Chen, P Pang… - Frontiers in …, 2022 - frontiersin.org
… , and GLUT-1 and -4 depletion contribute to myocyte injury at the molecular level (15). …
However, until the early stage of diabetes, heart damage remains tiny and discrete. As the …

The role of microRNAs in the pathophysiology, diagnosis, and treatment of diabetic cardiomyopathy

M Abdel Rhman, P Owira - Journal of Pharmacy and …, 2022 - academic.oup.com
Diabetic Cardiomyopathy (DCM) is a macrovascular complication of DM that occurs in 12%
of DM patients. DCM is defined as a pathophysiological condition of the heart induced by …

Emerging role of epigenetics and miRNA in diabetic cardiomyopathy

M Asrih, S Steffens - Cardiovascular Pathology, 2013 - Elsevier
molecular aspects of diabetic cardiomyopathy have been introduced; in this section, studies
providing evidence for a role of epigenetics in the development of diabetic cardiomyopathy