Akebia Saponin D ameliorated kidney injury and exerted anti-inflammatory and anti-apoptotic effects in diabetic nephropathy by activation of NRF2/HO-1 and …

C Lu, G Fan, D Wang - International Immunopharmacology, 2020 - Elsevier
Diabetic nephropathy (DN), a common microvascular complication of type 2 diabetes
This study was designed to investigate the critical role of Akebia saponin D (ASD) in kidney …

[HTML][HTML] Administration of Akebia Saponin D Improved Blood Lipid Levels and Pregnancy Outcomes in Mice with Gestational Diabetes Mellitus

W Chen, J Shi, W Zhang - Balkan Medical Journal, 2023 - ncbi.nlm.nih.gov
… isolated from the Radix Dipsaci, 13 has been shown to reduce blood glucose and increase
insulin levels in diabetic nephropathy mice. Consistently, ASD reduced body weight, …

Akebia Saponin D suppresses inflammation in chondrocytes via the NRF2/HO-1/NF-κB axis and ameliorates osteoarthritis in mice

M Gu, J Jin, C Ren, X Chen, W Gao, X Wang, Y Wu… - Food & function, 2020 - pubs.rsc.org
Akebia Saponin D (ASD) is a main active component … that Akebia Saponin D suppresses
the NF-KB pathway by activating NRF2/HO-1, improves kidney damage in diabetic nephropathy

Akebia saponin D attenuates allergic airway inflammation through AMPK activation

L Xuan, S Yang, L Ren, H Liu, W Zhang, Y Sun… - Journal of Natural …, 2024 - Springer
Akebia saponin D (ASD), a triterpenoid saponin extracted from root of Dipsacus asper Wall.
ex DC., exhibited protective effects on many disorders, including hyperlipidemia, Alzheimer’…

… nephropathy progression via mitigating renal oxidative stress, inflammation, fibrosis and apoptosis in high fat diet and low dose streptozotocin-induced diabetic rats

NA Abd Wahab, N Giribabu, EK Kilari, N Salleh - Phytomedicine, 2022 - Elsevier
Diabetic nephropathy (DN) is one of the complications of diabetes mellitus (DM), which can
… Suggested mechanisms of AA protective effect against diabetic nephropathy. As a result of …

Integrated network pharmacology and pharmacological investigations to discover the active compounds of Toona sinensis pericarps against diabetic nephropathy

H Li, R Wang, Y Chen, M Zhao, S Lan, C Zhao… - Journal of …, 2024 - Elsevier
Diabetic nephropathy (DN) is the leading reason of chronic kidney disease, and one of the
… to visualize the overlap between the targets of TCMSP prediction and Diabetic Nephropathy. …

Akebia trifoliata pericarp extract ameliorates inflammation through NF-κB/MAPK signaling pathways and modifies gut microbiota

X Wang, N Yu, Z Wang, T Qiu, L Jiang, X Zhu, Y Sun… - Food & function, 2020 - pubs.rsc.org
… In addition, previous research showed that triterpenoid is the main component of Akebia,
and our research also proves this point. About 10 types of saponins were tentatively identified …

Herbal nephropathy

R Claure-Del Granado… - Nephrology and Public …, 2021 - karger.com
… longepedunculata (violet tree) that contains methyl salicylate and saponin; Euphorbia … to
diabetic nephropathy [41– 43]. Khajehdehi et al. [44] randomized diabetic nephropathy patients …

Targeting autophagy using saponins as a therapeutic and preventive strategy against human diseases

B Han, C He - Pharmacological Research, 2021 - Elsevier
… some saponins are reported to modulate autophagy. Research suggests that saponins may
… Therefore, this review comprehensively summarizes and discusses the reported saponins

Bioactive compounds effective against type 2 diabetes mellitus: a systematic review

C Egbuna, CG Awuchi, G Kushwaha… - Current Topics in …, 2021 - ingentaconnect.com
… may be induced by type 2 diabetes mellitus. Some acute complications (diabetic retinopathy,
diabetic nephropathy, diabetic neuropathy) are mainly connected to high mortality in …