Mitochondrial dysfunction in diabetic neuropathy: a series of unfortunate metabolic events

P Fernyhough - Current diabetes reports, 2015 - Springer
… is a dying back neurodegenerative disease of the peripheral nervous system where
mitochondrial dysfunction has been implicated as an etiological factor. Diabetes (type 1 or type 2) …

Mechanism of mitochondrial dysfunction in diabetic sensory neuropathy

P Fernyhough, TJ Huang… - Journal of the Peripheral …, 2003 - Wiley Online Library
… of diabetic neuropathy based … mitochondrial membrane potential in cultured adult sensory
neurons. We therefore tested the hypothesis that diabetes-induced mitochondrial dysfunction

Diabetic peripheral neuropathy: evidence for apoptosis and associated mitochondrial dysfunction.

S Srinivasan, M Stevens, JW Wiley - Diabetes, 2000 - Am Diabetes Assoc
diabetic sensory neuropathy is associated with activation of apoptosis and concomitant
mitochondrial dysfunction… streptozotocininduced diabetic rats with decreased peripheral nerve …

Mechanisms of disease: mitochondria as new therapeutic targets in diabetic neuropathy

GM Leinninger, JL Edwards, MJ Lipshaw… - Nature Clinical Practice …, 2006 - nature.com
Diabetic neuropathy (DN) is the most common complication of diabetes mellitus, and it …
This Review will survey the mechanisms of mitochondrial degeneration in the pathogenesis …

Oxidative stress and mitochondrial dysfunction associated with peripheral neuropathy in type 1 diabetes

E Eftekharpour, P Fernyhough - Antioxidants & Redox Signaling, 2022 - liebertpub.com
… (Type 1 Diabetes) … literature describing varying aspects of mitochondrial dysfunction in
sensory neurons in the context of type 1 diabetes and diabetic neuropathy, and then relate to …

The oxidative stress and mitochondrial dysfunction during the pathogenesis of diabetic retinopathy

MY Wu, GT Yiang, TT Lai, CJ Li - Oxidative medicine and …, 2018 - Wiley Online Library
… The imbalance in the potential energy reduction process was reported in a study examining
mitochondrial dysfunction during DR pathogenesis. An excess of glucose in diabetes is …

Mitochondrial dysfunction in chemotherapy-induced peripheral neuropathy (CIPN)

A Canta, E Pozzi, VA Carozzi - Toxics, 2015 - mdpi.com
… The mitochondrial dysfunction has a critical role in several disorders including
chemotherapy-induced peripheral neuropathies (CIPN). This is due to a related dysregulation of …

Mitochondrial dysfunction and mitophagy: the beginning and end to diabetic nephropathy?

GC Higgins, MT Coughlan - British journal of pharmacology, 2014 - Wiley Online Library
mitochondrial dysfunction can lead to intrinsic cell death. Ultimately, the question of whether
mitochondrial dysfunction is … Without healthy mitochondria, cellular homeostasis within the …

Mitochondrial dysfunction and complications associated with diabetes

R Blake, IA Trounce - Biochimica et Biophysica Acta (BBA)-General …, 2014 - Elsevier
… These changes lead to a number of secondary diseases, such as cardiovascular disease,
diabetic retinopathy, nephropathy and neuropathy. Here, we first discuss normal blood …

Research progress on mitochondrial dysfunction in diabetic retinopathy

Y Wu, H Zou - Antioxidants, 2022 - mdpi.com
… modification [9], etc., while mitochondrial dysfunction induced by high glucose, as a well-…
article reviews the mechanism of diabetic retinopathy induced by mitochondrial dysfunction. …