Mitochondrial dysfunction accompanies diastolic dysfunction in diabetic rat heart

CE Flarsheim, IL Grupp… - … of Physiology-Heart and …, 1996 - journals.physiology.org
… rotenone to block site 1 of the electron transport chain, mitochondria from diabetic rat hearts
exhibited no marked difference from control mitochondria after 8 wk of diabetes (Fig. 7C). …

Diabetes and mitochondrial oxidative stress: a study using heart mitochondria from the diabetic Goto-Kakizaki rat

DL Santos, CM Palmeira, R Sei% ccedil; a… - Molecular and cellular …, 2003 - Springer
… We observed that oxidative damage induced in heart mitochondria of diabetic rats showed
… shows that heart mitochondria from diabetic rats differ significantly from non-diabetic rats in …

Quantitative protein profiling in heart mitochondria from diabetic rats

IV Turko, F Murad - Journal of Biological Chemistry, 2003 - ASBMB
… of alterations caused by diabetes in heart mitochondria from streptozotocin-treated rats. We
… myocardial tricarboxylic acid cycle was not altered in diabetes. However, up-regulation of the …

Mitochondrial dysfunction observed in situ in cardiomyocytes of rats in experimental diabetes

Y Tanaka, N Konno, KJ Kako - Cardiovascular research, 1992 - academic.oup.com
… The uptake by mitochondria of diabetic rat hearts was significantly lower, but was … Ca'' efflux
from the heart mitochondria is regulated by a Na+/Ca2' exchange mechanism, whereas Ca2' …

The mitochondria in diabetic heart failure: from pathogenesis to therapeutic promise

D SchillingJoel - Antioxidants & redox signaling, 2015 - liebertpub.com
… In support of this approach, short-term CPT1 inhibition with etomoxir prevents the
development of contractile dysfunction in a rat model of diabetic CM (87). However, a potential …

Mitochondrial inefficiencies and anoxic ATP hydrolysis capacities in diabetic rat heart

T Pham, D Loiselle, A Power… - American Journal of …, 2014 - journals.physiology.org
… supply 95% of the heart's ATP, and diabetic heart mitochondria show impaired structure, …
are present in diabetic heart mitochondria; therefore, we explored mitochondrial proton and …

Attenuation of Ca2+ homeostasis, oxidative stress, and mitochondrial dysfunctions in diabetic rat heart: insulin therapy or aerobic exercise?

MF da Silva, AJ Natali, E da Silva… - Journal of Applied …, 2015 - journals.physiology.org
heart mitochondria of STZ-induced diabetic rats, inasmuch as Nox-4 activity leads to cysteine
oxidation of mitochondrial … of the MPTP complex and mitochondrial damage, as reported …

[HTML][HTML] Enhanced permeability transition explains the reduced calcium uptake in cardiac mitochondria from streptozotocin-induced diabetic rats

PJ Oliveira, R Seiça, PM Coxito, AP Rolo, CM Palmeira… - FEBS letters, 2003 - Elsevier
mitochondria, resulting in decreased mitochondrial calcium accumulation. We also observed
that heart mitochondria from diabetic ratsmitochondrial calcium uptake observed in heart

Heart mitochondrial dysfunction in diabetic rats

SS Bombicino, DE Iglesias, IA Rukavina Mikusic… - 2016 - notablesdelaciencia.conicet.gov.ar
… production were present in hearts of diabetic animals. We observed an increase in NO
production by heart mitochondria and in cytochrome oxidase activity in heart homogenates. The …

Superoxide and respiratory coupling in mitochondria of insulin-deficient diabetic rats

JA Herlein, BD Fink, Y O'Malley, WI Sivitz - Endocrinology, 2009 - academic.oup.com
… muscle and heart tissue and in heart mitochondria, whereas … mitochondria of diabetic rats.
We conclude that gastrocnemius, heart, and liver mitochondria of streptozotocin diabetic rats