iTRAQ-based quantitative proteomic analysis of submandibular glands from rats with STZ-induced hyperglycemia

RMP Alves, R Vitorino, AI Padrao… - The journal of …, 2013 - academic.oup.com
… structural changes were … changes at 6 months of exposure (10). Nonetheless, the biochemical
events underlying such structural changes remain largely undisclosed and a proteomic

Diabetes mellitus in the era of proteomics

M Korc - Molecular & Cellular Proteomics, 2003 - ASBMB
… Another major form of diabetes mellitus is type 1 diabetes mellitus (T1DM). These patients
… of diabetes that are based on proteomics-driven technology. TYPE 2 DIABETES MELLITUS …

Proteomic profile of the lens in a streptozotocin‑induced diabetic rat model using shotgun proteomics

N Nagai, T Yamamoto, K Mitamura… - Biomedical …, 2017 - spandidos-publications.com
… was changed in the diabetic rat model was investigated using shotgun proteomics. In the
lenses of the STZ rats, 235 proteins were identified and 229 were identified in that of the normal …

Detection of differential proteomes associated with the development of type 2 diabetes in the Zucker rat model using the iTRAQ technique

D Han, S Moon, H Kim, SE Choi, SJ Lee… - Journal of proteome …, 2011 - ACS Publications
… To investigate the molecular changes from obese prediabetes to obese diabetes, we applied
the methods of hierarchical clustering and manual grouping to the differential proteome, …

Analysis of modification of liver proteome in diabetic rats by 2d electrophoresis and MALDI-TOF-MS

D Karthik, S Ilavenil, B Kaleeswaran… - Indian Journal of Clinical …, 2012 - Springer
… The aim of the present study is to characterize the liver proteome changes in alloxan-induced
diabetes. In this study, we have identified three up-regulated proteins and classified them …

A novel approach of proteomics to study the mechanism of action of grape seed proanthocyanidin extracts on diabetic retinopathy in rats

M Li, Y Ma, H Gao, B Li, M Cheng, L Xu, X Li… - Chinese medical …, 2008 - mednexus.org
… proteins changed in diabetic rats, wherein 7 changed … up.regulated in the retina of
diabetic rats and back—regulated to … some changed proteins in diabetic rats did not back—regulate …

Proteomics and diabetic nephropathy

ML Merchant, JB Klein - Seminars in nephrology, 2007 - Elsevier
… been used in recent proteomic investigations including the … fatty rat, KK mouse, and
Ostuka-Evans Tokushima Fatty rats. … methods and will result in the research workflow changing

Proteome changes induced by laser in diabetic retinopathy

GJ Quin, B Lyons, ACL Len… - Clinical & …, 2015 - Wiley Online Library
… retinopathy is breakdown of the blood-retinal barrier.8, 9 Anatomical and cellular changes
compared the proteome profiles of normal rat retinae and rat retinae with diabetic retinopathy.…

Proteomic profile of primary isolated rat mesangial cells in high-glucose culture condition and decreased expression of PSMA6 in renal cortex of diabetic rats

Z Li, H Zhang, X Dong, FJ Burczynski… - … and cell biology, 2010 - cdnsciencepub.com
… In addition, the study did not reveal any proteomic changes after different lengths of incubation
with high glucose. Therefore, in the current study, we employed proteomic techniques to …

Study of diabetic nephropathy in the proteomic era

V Thongboonkerd - Diabetes and the Kidney, 2011 - karger.com
… to identify changes in cellular proteome of ratrat mesangial cells under the high- glucose
condition, but also in streptozotocin- induced diabetic rats and spontaneous OLETF diabetic rat