Heme oxygenase-1 enhances renal mitochondrial transport carriers and cytochrome C oxidase activity in experimental diabetes

MA Di Noia, S Van Driesche, F Palmieri… - Journal of Biological …, 2006 - ASBMB
… the restoration of MCs in diabetic rats. Human HO-1 cDNA transfer into diabetic rats increased
both HO-1 protein and activity, and restored mitochondrial ADP/ATP and deoxynucleotide …

[HTML][HTML] Chronic high glucose downregulates mitochondrial calpain 10 and contributes to renal cell death and diabetes-induced renal injury

MD Covington, RG Schnellmann - Kidney international, 2012 - Elsevier
… Our data reveal that diabetic glucose specifically decreases mitochondrial calpain 10
expression in RPTCs and that renal calpain 10 is decreased in diabetic rats and mice. Furthermore…

Renal mitochondrial oxidative stress is enhanced by the reduction of Sirt3 activity, in Zucker diabetic fatty rats

Y Ogura, M Kitada, I Monno, K Kanasaki… - Redox …, 2018 - Taylor & Francis
… the mechanism of mitochondrial oxidative stress in the diabetic kidney. In this … renal
mitochondria from diabetic rats, indicating that mitochondrial Sirt3 activity was reduced in the diabetic

[PDF][PDF] Mitochondrion and its role in diabetic nephropathy

F Khoshjou, F Dadras - Iranian journal of kidney diseases, 2014 - academia.edu
… of rat renal tubular cells, mitochondrial fragmentation was observed prior to cytochrome c
release and apoptosis. Dynamin-related protein 1 translocated to mitochondria … of diabetic rats.…

Mitochondrial activity contributes to impaired renal metabolic homeostasis and renal pathology in STZ-induced diabetic mice

M Wu, S Li, X Yu, W Chen, H Ma… - … Physiology-Renal …, 2019 - journals.physiology.org
… early diabetic kidney with or without the inhibition of mitochondrialmitochondrial complex-1
activity in the diabetic kidney, which was completely normalized by the specific mitochondrial

Early protective effect of mitofusion 2 overexpression in STZ-induced diabetic rat kidney

WX Tang, WH Wu, XX Zeng, H Bo, SM Huang - Endocrine, 2012 - Springer
… , mitochondrial function, and apoptosis were evaluated and compared with diabetic rats
has also been demonstrated in ischemic and in nephrotoxic models of acute renal failure. …

Mitochondrial energetics in the kidney

P Bhargava, RG Schnellmann - Nature Reviews Nephrology, 2017 - nature.com
mitochondrial biogenesis can restore mitochondrial and renal function in mouse models of
AKI and diabetes … and diabetic nephropathy as examples of how mitochondrial dysfunction …

[HTML][HTML] Hyperglycemia induced damage to mitochondrial respiration in renal mesangial and tubular cells: Implications for diabetic nephropathy

A Czajka, AN Malik - Redox biology, 2016 - Elsevier
… A faulty bioenergetic profile was observed in cultured neurons derived from streptozotocin
induced diabetic rats with decreased maximal respiration and decreased spare capacity [39]. …

Alterations in renal mitochondrial respiration in response to the reactive oxoaldehyde methylglyoxal

MG Rosca, VM Monnier, LI Szweda… - … of Physiology-Renal …, 2002 - journals.physiology.org
… a renal mitochondrial toxin, independent of the intracellular glucose level. Intact mitochondria
isolated from rat renal … the effects of MGO on mitochondrial respiratory rates, the conditions …

[HTML][HTML] … ameliorates mitochondrial oxidative stress through restoration of the intracellular NAD+/NADH ratio and Sirt3 activity in renal tubular cells in diabetic rats

Y Ogura, M Kitada, J Xu, I Monno, D Koya - Aging (Albany NY), 2020 - ncbi.nlm.nih.gov
… to the pathogenesis of diabetic kidney disease (DKD). We previously showed that
mitochondrial oxidative stress in the kidneys of Zucker diabetic fatty rats is associated with a …