Evidence for lymphatic transport of insulin by topically applied biphasic vesicles

MJ King, D Michel, M Foldvari - Journal of pharmacy and …, 2003 - Wiley Online Library
… involvement of the lymphatic pathway for insulin by topical administration of biphasic vesicles
in a diabetic rat model. Here we show that insulin delivered through the skin using a needle…

[Retracted] Insulin Topical Application for Wound Healing in Nondiabetic Patients

S Sun, L Zhang, J Liu, H Li - Computational and mathematical …, 2021 - Wiley Online Library
… the efficacy of topical insulin. Therefore, this study is aimed at reviewing how topical insulin
affected granulation tissue … In diabetic rats with dry eye syndrome, it was reported that …

Insulin complexed with cyclodextrins stimulates epithelialization and neovascularization of skin wound healing in rats

JCF Besson, L Hernandes, JM de Campos… - Injury, 2017 - Elsevier
… during the differentiation process; and (D) the number of blood vessels in the dermis after
topical application of base gel; insulin gel; and Hydroxy-propyl-β-cyclodextrin complexed with …

Effect of topical mixture of honey, royal jelly and olive oil-propolis extract on skin wound healing in diabetic rats

MK Rashidi, N Mirazi, A Hosseini - Wound Medicine, 2016 - Elsevier
… Animals were made insulin-dependent diabetic by intraperitoneal injection of 60 mg kg −1
body weight STZ. After 3 days following STZ administration, blood samples were taken from …

Transdermal delivery of insulin by amidated pectin hydrogel matrix patch in streptozotocin-induced diabetic rats: effects on some selected metabolic parameters

SI Hadebe, PS Ngubane, MR Serumula… - PloS one, 2014 - journals.plos.org
insulin concentrations of untreated diabetic rats were low compared with control non-diabetic
ratsrats following topical application of pectin insulin-containing dermal matrix patches, we …

A study of effectiveness of topical insulin on healing of diabetic ulcers at tertiary health care centre: a cross sectional study from Puducherry

PB Thakur, T Ramachandrudu… - International Surgery …, 2020 - ijsurgery.com
… to group A which was given topical insulin application with routine conventional management
topical insulin dressing accelerates wound healing in the skin of diabetic rats and humans.…

Microemulsions for oral delivery of insulin: design, development and evaluation in streptozotocin induced diabetic rats

G Sharma, K Wilson, CF Van der Walle, N Sattar… - European Journal of …, 2010 - Elsevier
… The conformational stability of the entrapped insulin within … with plain insulin solution
administered per oral in healthy rats. The short-term in vivo efficacy in STZ induced diabetic rats

[PDF][PDF] A randomized, double-blind, placebo-controlled trial to determine the effects of topical insulin on wound healing

O Rezvani, E Shabbak, A Aslani, R Bidar… - Ostomy/wound …, 2009 - researchgate.net
… In this study, the use of topical insulin was safe and effective. Although wound healing rates
… Effect of topical insulin on cutaneous wound healing in rats with or without acute diabetes. …

Hollow metal microneedles for insulin delivery to diabetic rats

SP Davis, W Martanto, MG Allen… - IEEE Transactions on …, 2005 - ieeexplore.ieee.org
… and delivery of insulin to modulate the blood glucose level of diabetic rats are also reported.
… Negative control experiments showed that topical insulin without microneedles produced …

Insulin for topical use in wound healing: opportunities and limitations

BM Benkő - Acta Pharmaceutica Hungarica, 2022 - real.mtak.hu
… The present study aims to explore the opportunities and limitations of topical insulin (TI) …
Topical insulin accelerates cutaneous wound healing in insulin-resistant diabetic rats. Am J …