Covariate adjustment in randomized controlled trials with dichotomous outcomes increases statistical power and reduces sample size requirements

AV Hernández, EW Steyerberg… - Journal of clinical …, 2004 - Elsevier
covariate adjustment in simulated logistic regression models with one dichotomous covariate
Our aim was to identify the pros and the cons of each covariate adjustment strategy, with a …

[PDF][PDF] A practical guide for multivariate analysis of dichotomous outcomes

J Lee, CS Tan, KS Chia - Ann Acad Med Singapore, 2009 - Citeseer
Dichotomous Outcomes—James Lee et al suitable for adjusting for 1 or at most 2 confounding
covariates … Moreover, a continuous covariate (age, blood pressure) must be grouped into …

Randomized controlled trials with time-to-event outcomes: how much does prespecified covariate adjustment increase power?

AV Hernández, MJC Eijkemans, EW Steyerberg - Annals of epidemiology, 2006 - Elsevier
… β is coefficient of the covariate effect, U is random dichotomous value of treatment with 50%
prevalence for treatment A on average, and V is random dichotomous value of covariate at a …

Instrumental variable analysis for estimation of treatment effects with dichotomous outcomes

JA Rassen, S Schneeweiss, RJ Glynn… - American journal of …, 2009 - academic.oup.com
… ; each of these covariates was controlled for in the adjusted analyses. … For our dichotomous
outcome, we attempted to use … and without covariates. In almost all cases, the models without …

A comparison of methods to adjust for continuous covariates in the analysis of randomised trials

BC Kahan, H Rushton, TP Morris, RM Daniel - BMC medical research …, 2016 - Springer
… ) adjusting for continuous covariates even if their association with outcome is unknown; (2)
keeping covariates … we assume that the covariate does influence outcome. It should be noted …

Nonparametric randomization-based covariate adjustment for stratified analysis of time-to-event or dichotomous outcomes

MA Hussey, GG Koch, JS Preisser… - Journal of …, 2016 - Taylor & Francis
… of Covariance) methods as they relate to dichotomous outcomes in this paper, the primary
outcome for this analysis was the Yes/No outcome of whether a patient progressed by 12 …

Regression discontinuity was a valid design for dichotomous outcomes in three randomized trials

N van Leeuwen, HF Lingsma, SP Mooijaart… - Journal of clinical …, 2018 - Elsevier
… the baseline variable in the adjustment model for optimal adjustment. To consider a …
adjustment model. R 2 statistics were calculated to indicate the explained variance of the adjustment

Analysis of dichotomous outcome data for community intervention studies

SL Bellamy, R Gibberd, L Hancock… - … Methods in Medical …, 2000 - journals.sagepub.com
… and cluster level covariates that must be … adjustment to the standard error of the regression
parameter estimate from the ordinary logistic regression approach, we do get an adjusted

Covariate adjustment in randomized trials with binary outcomes: targeted maximum likelihood estimation

KL Moore, MJ van der Laan - Statistics in medicine, 2009 - Wiley Online Library
… in randomized controlled trials with dichotomous outcomes increases statistical power
and reduces sample size requirements. Journal of Clinical Epidemiology 2004; 57(5):454–460. …

Robust estimation of causal effects of binary treatments in unconfounded studies with dichotomous outcomes

R Gutman, DB Rubin - Statistics in Medicine, 2013 - Wiley Online Library
… across units, we must usually consider the third type of variable, the covariates, X i . A key …
any adjustments beyond grouping observations that are similar in terms of the covariate. Rubin …