Sensing a paradigm shift in the field of molecular recognition: from selective to differential receptors
JJ Lavigne, EV Anslyn - Angewandte Chemie International …, 2001 - Wiley Online Library
… Certainly the use of chemical libraries for creating receptors from synthetic compounds will
be … explore herein, this method is ideal for the creation of differential or generalized receptors. …
be … explore herein, this method is ideal for the creation of differential or generalized receptors. …
Differential recognition of target genes by nuclear receptor monomers, dimers, and heterodimers
CK Glass - Endocrine reviews, 1994 - academic.oup.com
… underlie the differential abilities of various nuclear receptors to discriminate between …
recognition motif, protein-protein contacts between the DBDs of dimeric or heterodimeric receptors, …
recognition motif, protein-protein contacts between the DBDs of dimeric or heterodimeric receptors, …
Differential recognition of structural details of bacterial lipopeptides by toll‐like receptors
M Morr, O Takeuchi, S Akira, MM Simon… - European journal of …, 2002 - Wiley Online Library
… biological activity and respective host cell receptors was examined with synthetic variants
of … of varioustoll-like receptors (TLR) were the indicator cells to study receptor requirements, …
of … of varioustoll-like receptors (TLR) were the indicator cells to study receptor requirements, …
Differential receptor arrays and assays for solution-based molecular recognition
… Herein we present a tutorial review on differential receptor arrays for solution-based assays.
… There is already a wealth of information available on differential vapor and solution phase …
… There is already a wealth of information available on differential vapor and solution phase …
Differential recognition of CD1d-α-galactosyl ceramide by the Vβ8. 2 and Vβ7 semi-invariant NKT T cell receptors
DG Pellicci, O Patel, L Kjer-Nielsen, SS Pang… - Immunity, 2009 - cell.com
… The semi-invariant natural killer T cell receptor (NKT TCR) recognizes CD1d-lipid antigens.
… Collectively we provide a structural basis for the differential NKT TCR Vβ usage in NKT cells…
… Collectively we provide a structural basis for the differential NKT TCR Vβ usage in NKT cells…
Differential recognition of TLR-dependent microbial ligands in human bronchial epithelial cells
AK Mayer, M Muehmer, J Mages… - The Journal of …, 2007 - journals.aai.org
… To assure the functional expression of the detected receptors we stimulated BEAS-2B cells
with highly purified specific ligands (Fig. 1, a and b). Ligands for TLR1 (P3C), −2 (P3C, LTA, R…
with highly purified specific ligands (Fig. 1, a and b). Ligands for TLR1 (P3C), −2 (P3C, LTA, R…
Differential recognition of double-stranded RNA by RIG-I–like receptors in antiviral immunity
… (17) in this issue describes a plausible mechanism of RNA ligand recognition by MDA5,
providing new insights into the differential roles of RLRs. The study reveals that MDA5 binding to …
providing new insights into the differential roles of RLRs. The study reveals that MDA5 binding to …
Differential pattern recognition receptor expression but stereotyped responsiveness in rat spleen dendritic cell subsets
FX Hubert, C Voisine, C Louvet, JM Heslan… - The Journal of …, 2006 - journals.aai.org
… specialization in pathogen recognition capacity and immune functions of DC subsets is
relatively conserved between species. Our results indicate that the differential expression of PRR …
relatively conserved between species. Our results indicate that the differential expression of PRR …
Differential signaling by lymphocyte antigen receptors
J Alberola-Ila, S Takaki, JD Kerner… - Annual review of …, 1997 - annualreviews.org
… The time-constant of theinteraction between antigen and receptor in this way determines, at
… on T cell receptor signaling, we have included a lessdetailed description of B cell receptor …
… on T cell receptor signaling, we have included a lessdetailed description of B cell receptor …
A general approach to differential sensing using synthetic molecular receptors
AP Umali, EV Anslyn - Current opinion in chemical biology, 2010 - Elsevier
… In summary, our approach for differential sensing uses synthetic receptors biased to classes
of analytes of interest. The receptors have a core unit decorated with moieties that impart …
of analytes of interest. The receptors have a core unit decorated with moieties that impart …
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