Sensing a paradigm shift in the field of molecular recognition: from selective to differential receptors

JJ Lavigne, EV Anslyn - Angewandte Chemie International …, 2001 - Wiley Online Library
… Certainly the use of chemical libraries for creating receptors from synthetic compounds will
be … explore herein, this method is ideal for the creation of differential or generalized receptors. …

Differential recognition of target genes by nuclear receptor monomers, dimers, and heterodimers

CK Glass - Endocrine reviews, 1994 - academic.oup.com
… underlie the differential abilities of various nuclear receptors to discriminate between …
recognition motif, protein-protein contacts between the DBDs of dimeric or heterodimeric receptors, …

Differential recognition of structural details of bacterial lipopeptides by toll‐like receptors

M Morr, O Takeuchi, S Akira, MM Simon… - European journal of …, 2002 - Wiley Online Library
… biological activity and respective host cell receptors was examined with synthetic variants
of … of varioustoll-like receptors (TLR) were the indicator cells to study receptor requirements, …

Differential receptor arrays and assays for solution-based molecular recognition

AT Wright, EV Anslyn - Chemical Society Reviews, 2006 - pubs.rsc.org
… Herein we present a tutorial review on differential receptor arrays for solution-based assays.
… There is already a wealth of information available on differential vapor and solution phase …

Differential recognition of CD1d-α-galactosyl ceramide by the Vβ8. 2 and Vβ7 semi-invariant NKT T cell receptors

DG Pellicci, O Patel, L Kjer-Nielsen, SS Pang… - Immunity, 2009 - cell.com
… The semi-invariant natural killer T cell receptor (NKT TCR) recognizes CD1d-lipid antigens.
… Collectively we provide a structural basis for the differential NKT TCR Vβ usage in NKT cells

Differential recognition of TLR-dependent microbial ligands in human bronchial epithelial cells

AK Mayer, M Muehmer, J Mages… - The Journal of …, 2007 - journals.aai.org
… To assure the functional expression of the detected receptors we stimulated BEAS-2B cells
with highly purified specific ligands (Fig. 1, a and b). Ligands for TLR1 (P3C), −2 (P3C, LTA, R…

Differential recognition of double-stranded RNA by RIG-I–like receptors in antiviral immunity

T Saito, M Gale Jr - The Journal of experimental medicine, 2008 - rupress.org
… (17) in this issue describes a plausible mechanism of RNA ligand recognition by MDA5,
providing new insights into the differential roles of RLRs. The study reveals that MDA5 binding to …

Differential pattern recognition receptor expression but stereotyped responsiveness in rat spleen dendritic cell subsets

FX Hubert, C Voisine, C Louvet, JM Heslan… - The Journal of …, 2006 - journals.aai.org
… specialization in pathogen recognition capacity and immune functions of DC subsets is
relatively conserved between species. Our results indicate that the differential expression of PRR …

Differential signaling by lymphocyte antigen receptors

J Alberola-Ila, S Takaki, JD Kerner… - Annual review of …, 1997 - annualreviews.org
… The time-constant of theinteraction between antigen and receptor in this way determines, at
… on T cell receptor signaling, we have included a lessdetailed description of B cell receptor

A general approach to differential sensing using synthetic molecular receptors

AP Umali, EV Anslyn - Current opinion in chemical biology, 2010 - Elsevier
… In summary, our approach for differential sensing uses synthetic receptors biased to classes
of analytes of interest. The receptors have a core unit decorated with moieties that impart …