Impact of regulatory variation across human iPSCs and differentiated cells

NE Banovich, YI Li, A Raj, MC Ward… - Genome …, 2018 - genome.cshlp.org
… Interestingly, we find the increased variation in differentiated cell types is also associated …
genes (Supplemental Materials), further highlighting the level of regulatory control in iPSCs. …

Generation of iPSCs from cultured human malignant cells

JE Carette, J Pruszak, M Varadarajan… - Blood, The Journal …, 2010 - ashpublications.org
… other human cancer cells can be reprogrammed into iPSCs. Interestingly, the oncogenic
mutations present in the reprogrammed KBM7-iPSCs do not fully prevent cellular differentiation

Differentiation of human iPSCs into functional podocytes

C Rauch, E Feifel, G Kern, C Murphy, F Meier… - PloS one, 2018 - journals.plos.org
… method to generate podocyte-like cells from human iPSCs. This represents a minimal invasive
and ethically accepted way to obtain human podocytes in appropriate quantities for basic …

Molecular and functional resemblance of differentiated cells derived from isogenic human iPSCs and SCNT-derived ESCs

MT Zhao, H Chen, Q Liu, NY Shao… - Proceedings of the …, 2017 - National Acad Sciences
human iPSCs and SCNT-ESC derivatives. We provide proof-of-concept that differentiated
cells derived from human iPSCs are … We conclude that human iPSCs are capable of replacing …

[HTML][HTML] Hepatocyte-like cells differentiated from human induced pluripotent stem cells: relevance to cellular therapies

Y Yu, H Liu, Y Ikeda, BP Amiot, P Rinaldo, SA Duncan… - Stem cell …, 2012 - Elsevier
… to assess the differentiation status and functionality of three human cell types (hiPSCs, …
usefulness in human cell therapy. Functionality and differentiation of these three cell types were …

Differentiation of human induced pluripotent stem cells into erythroid cells

M Ebrahimi, M Forouzesh, S Raoufi, M Ramazii… - Stem Cell Research & …, 2020 - Springer
… of HSCs from human iPSCs. Many studies have aimed to differentiate human iPSCs into
RBCs … In general, there are three steps for differentiation of iPSCs into RBCs, including the …

Robust detection of undifferentiated iPSC among differentiated cells

K Sekine, S Tsuzuki, R Yasui, T Kobayashi, K Ikeda… - Scientific reports, 2020 - nature.com
… whether undifferentiated iPSCs were present in the differentiated cells in the … differentiated
cells and cultivated them for ~1 week in iPSC maintenance state to derive undifferentiated cell

Improved approach for chondrogenic differentiation of human induced pluripotent stem cells

H Nejadnik, S Diecke, OD Lenkov, F Chapelin… - Stem Cell Reviews and …, 2015 - Springer
differentiation, our approach involves direct induction of human mesenchymal stem/stromal
cells … -derived chondrogenic differentiated cell pellets after 3 weeks of differentiation (3 knees…

Neural differentiation of human induced pluripotent stem cells follows developmental principles but with variable potency

BY Hu, JP Weick, J Yu, LX Ma… - Proceedings of the …, 2010 - National Acad Sciences
… improved differentiation. Here, we compared the neural-differentiation potential of human
iPSCs, … We found that human iPSCs differentiate to neuroepithelial (NE) cells and functional …

Efficient differentiation of human iPSC‐derived mesenchymal stem cells to chondroprogenitor cells

RM Guzzo, J Gibson, RH Xu, FY Lee… - Journal of cellular …, 2013 - Wiley Online Library
… vitro conditions for efficient differentiation to the chondrocytic … progenitor cell population from
differentiating human iPSCs and … of iPSCs and limiting the heterogeneity of the differentiated