Improved dissolution and pharmacokinetic behavior of dipyridamole formulation with microenvironmental pH-modifier under hypochlorhydria
S Onoue, R Inoue, C Taniguchi, Y Kawabata… - International journal of …, 2012 - Elsevier
… new formulations of dipyridamole (DP), a pH-dependent poorly soluble drug, employing an
acidic pH-modifier … Granule formulations of DP (DPG) with and without fumaric acid (FA) were …
acidic pH-modifier … Granule formulations of DP (DPG) with and without fumaric acid (FA) were …
Novel formulations of dipyridamole with microenvironmental pH-modifiers for improved dissolution and bioavailability under hypochlorhydria
C Taniguchi, R Inoue, Y Kawabata, K Yamashita… - International journal of …, 2012 - Elsevier
… -releases formulation of DP with pH-modifier for enhancing … formulations of DP (DPG) with
seven acidic pH-modifiers … Selection of appropriate acid and formulation optimization were …
seven acidic pH-modifiers … Selection of appropriate acid and formulation optimization were …
Development and evaluation of dipyridamole sustained release tablets containing micro-environmental pH modifiers
Z Xi, N Sharma, A Paprikar, S Lin - Journal of Drug Delivery Science and …, 2019 - Elsevier
… of dipyridamole, a poorly soluble weakly basic compound. The solubility of dipyridamole
is … were formulated containing organic acids as pH modifiers to regulate micro-environmental …
is … were formulated containing organic acids as pH modifiers to regulate micro-environmental …
[HTML][HTML] Improved dissolution of dipyridamole with the combination of pH-modifier and solid dispersion technology
Y Kojo, S Matsunaga, H Suzuki, C Taniguchi… - Chemical and …, 2017 - jstage.jst.go.jp
… a pH-independent release formulation of dipyridamole (DP) by the combined use of pH-modifier …
Tartaric acid (TA) was selected as an appropriate pH-modifier in terms of improving the …
Tartaric acid (TA) was selected as an appropriate pH-modifier in terms of improving the …
Rational selection of formulation components to improve dissolution of dipyridamole
M Maghsoodi, A Nokhodchi, HI Babi - Journal of Drug Delivery Science and …, 2020 - Elsevier
… polymer in solid dispersion formulations [22,… is pH-dependent could be improved by pH-modifier
technology [24]. Organic acids as pH-modifiers could reduce the microenvironmental pH …
technology [24]. Organic acids as pH-modifiers could reduce the microenvironmental pH …
Application of an in vitro dissolution/permeation system to early screening of oral formulations of poorly soluble, weakly basic drugs containing an acidic pH-modifier
M Mizoguchi, M Kataoka, K Yokoyama, R Aihara… - Journal of …, 2018 - Elsevier
… They included fumaric acid as a pH-modifier 18 because fumaric acid was reported not to
form a salt with dipyridamole. In this study, various formulations of dipyridamole including …
form a salt with dipyridamole. In this study, various formulations of dipyridamole including …
New Insight into Acidifier-Induced Enhancement of Dissolution of Weakly Basic Drug, Dipyridamole
M Maghsoodi, F Asghari, A Nokhodchi - Journal of Pharmaceutical …, 2023 - Springer
… The dipyridamole-acidifier formulations were prepared by … formulations, a pH-shift dissolution
test from pH 1.2 to neutral … of acidifier-based formulations containing dipyridamole, a model …
test from pH 1.2 to neutral … of acidifier-based formulations containing dipyridamole, a model …
[PDF][PDF] Development of pH independent drug release system for dipyridamole
… novel pH independent extended Dipyridamole tablets. Drug release is found completely pH
… importance of pH independent extended releases formulations with pH modulating agent, …
… importance of pH independent extended releases formulations with pH modulating agent, …
Microenvironmental pH-modification to improve dissolution behavior and oral absorption for drugs with pH-dependent solubility
C Taniguchi, Y Kawabata, K Wada… - Expert opinion on …, 2014 - Taylor & Francis
… excipients as a pH-modifier in the formulation, leading to pH-independent solubility. In the …
) were selected as appropriate pH-modifiers among ten acids for dipyridamole IR granules. A …
) were selected as appropriate pH-modifiers among ten acids for dipyridamole IR granules. A …
Evaluation of pH-independent sustained-release granules of dipyridamole by using gastric-acidity-controlled rabbits and human subjects
N Kohri, N Miyata, M Takahashi, H Endo, K Iseki… - International journal of …, 1992 - Elsevier
… at the preparation of a pH-independent sustained-release dosage form of dipyridamole,
the evaluation of the influence of gastric acidity on the bioavailability of dipyridamole and the …
the evaluation of the influence of gastric acidity on the bioavailability of dipyridamole and the …
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