Improved dissolution and pharmacokinetic behavior of dipyridamole formulation with microenvironmental pH-modifier under hypochlorhydria
S Onoue, R Inoue, C Taniguchi, Y Kawabata… - International journal of …, 2012 - Elsevier
The present study aimed to develop and characterize new formulations of dipyridamole (DP),
a pH-dependent poorly soluble drug, employing an acidic pH-modifier for improving …
a pH-dependent poorly soluble drug, employing an acidic pH-modifier for improving …
Pharmacokinetics of dipyridamole
F Nielsen‐Kudsk, AK Pedersen - Acta Pharmacologica et …, 1979 - Wiley Online Library
… of dipyridamole rather closely fits the pharmacokinetics of an … by the use of a corresponding
pharmacokinetic model with two … of 100 mg dipyridamole in tablets varied from 37 to 66%. …
pharmacokinetic model with two … of 100 mg dipyridamole in tablets varied from 37 to 66%. …
… -amorphous formulation of dipyridamole with p-hydroxybenzoic acid: Underlying molecular mechanisms, physical stability, dissolution behavior and pharmacokinetic …
W Guo, X Dong, Y Li, C Li, Y Tian, H Gao, T Li… - European Journal of …, 2023 - Elsevier
Coamorphization has been proven to be an effective approach to improve bioavailability of
poorly soluble active pharmaceutical ingredients (APIs) by virtue of solubilization, and also …
poorly soluble active pharmaceutical ingredients (APIs) by virtue of solubilization, and also …
Novel formulations of dipyridamole with microenvironmental pH-modifiers for improved dissolution and bioavailability under hypochlorhydria
C Taniguchi, R Inoue, Y Kawabata, K Yamashita… - International journal of …, 2012 - Elsevier
… to develop new dipyridamole (DP) formulations with acidic … Pharmacokinetic behavior of DP
was evaluated after oral … compare it with the pharmacokinetic behavior of DP in omeprazole-…
was evaluated after oral … compare it with the pharmacokinetic behavior of DP in omeprazole-…
Pharmacokinetics of dipyridamole-β-cyclodextrin complex in healthy volunteers after single and multiple doses
G Ricevuti, A Mazzone, D Pasotti, E Uccelli… - … and pharmacokinetics, 1991 - Springer
… It may be concluded that the improved pharmacological behaviour in several animal species,
the greater and more uniform bioavailability of dipyridamole after complexation, both in …
the greater and more uniform bioavailability of dipyridamole after complexation, both in …
Self-microemulsifying drug delivery system for improved oral bioavailability of dipyridamole: preparation and evaluation
F Guo, H Zhong, J He, B Xie, F Liu, H Xu, M Liu… - Archives of pharmacal …, 2011 - Springer
… The optimum formulation was 18% oleic acid, 12% Labrafac … assay indicated that
dipyridamole in SMEDDS dissolved … showed that dipyridamole in the SMEDDS formulation had a …
dipyridamole in SMEDDS dissolved … showed that dipyridamole in the SMEDDS formulation had a …
[HTML][HTML] The effect of dipyridamole on the pharmacokinetics of metformin: a randomized crossover study in healthy volunteers
S El Messaoudi, FG Russel, A Colbers… - European journal of …, 2016 - Springer
… metformin and the platelet aggregation inhibitor dipyridamole often occurs in patients with
… inhibited by dipyridamole in preclinical studies. We hypothesized that dipyridamole lowers …
… inhibited by dipyridamole in preclinical studies. We hypothesized that dipyridamole lowers …
Dipyridamole: pharmacokinetics and effects on aspects of platelet function in man.
D Gregov, A Jenkins, E Duncan… - British journal of …, 1987 - Wiley Online Library
… oral dipyridamole, and to render the effect of dipyridamole more … Pharmacokinetics of oral
dipyridamole(Persantin) and its … Effect of dipyridamole on human platelet behaviour. Lancet, …
dipyridamole(Persantin) and its … Effect of dipyridamole on human platelet behaviour. Lancet, …
Physiologically based pharmacokinetic model outputs depend on dissolution data and their input: Case examples glibenclamide and dipyridamole
L Klumpp, J Dressman - European Journal of Pharmaceutical Sciences, 2020 - Elsevier
… behavior. … pharmacokinetic profile of dipyridamole when data were inputted using the DRM,
while simulations from two-stage testing were most similar to the observed pharmacokinetic …
while simulations from two-stage testing were most similar to the observed pharmacokinetic …
New dipyridamole salt with improved dissolution and oral bioavailability under hypochlorhydric conditions
C Taniguchi, R Inoue, M Kato, K Yamashita… - … and Pharmacokinetics, 2013 - Elsevier
… of this study was to develop new dipyridamole (DP) salts with pH… Novel formulations of
dipyridamole with microenvironmental … pharmacokinetic behavior of dipyridamole formulation with …
dipyridamole with microenvironmental … pharmacokinetic behavior of dipyridamole formulation with …