Discovery and evaluation of entry inhibitors for SARS-CoV-2 and its emerging variants
… entry, using a combination of a computer-aided drug design (CADD) approach and cell-based
in vitro assays, we report the identification of five potential SARS-CoV-2 entry inhibitors. …
in vitro assays, we report the identification of five potential SARS-CoV-2 entry inhibitors. …
The appealing story of HIV entry inhibitors: from discovery of biological mechanisms to drug development
A Castagna, P Biswas, A Beretta, A Lazzarin - Drugs, 2005 - Springer
… of DC-associated virus is accessible to inhibitors during entry.[89] Of interest, in a recent
study where entry inhibitors of HIV-1 were evaluated for their ability to prevent infection of, and …
study where entry inhibitors of HIV-1 were evaluated for their ability to prevent infection of, and …
An updated review on betacoronavirus viral entry inhibitors: learning from past discoveries to advance COVID-19 drug discovery
… viral entry inhibitors of other coronaviruses, with special emphasis on β-CoVs entry inhibitors.
… This review highlighted several promising viral entry inhibitors as potential treatments for …
… This review highlighted several promising viral entry inhibitors as potential treatments for …
Discovery, synthesis, and biological evaluation of a novel group of selective inhibitors of filoviral entry
MV Yermolina, J Wang, M Caffrey… - Journal of medicinal …, 2011 - ACS Publications
Herein, we report the development of an antifiloviral screening system, based on a pseudotyping
strategy, and its application in the discovery of a novel group of small molecules that …
strategy, and its application in the discovery of a novel group of small molecules that …
Identification of a small-molecule entry inhibitor for filoviruses
A Basu, B Li, DM Mills, RG Panchal… - Journal of …, 2011 - Am Soc Microbiol
… an attractive target for therapy because inhibition of this step can … Anti-infective drug discovery
for EBOV presents significant … the discovery of a novel small-molecule entry inhibitor with …
for EBOV presents significant … the discovery of a novel small-molecule entry inhibitor with …
An update in the development of HIV entry inhibitors
S Rusconi, A Scozzafava… - Current topics in …, 2007 - ingentaconnect.com
… The discovery of the entry inhibitors, such as these chemokine antagonists presented
here, may lead to the development of a new generation of anti-HIV agents, since these …
here, may lead to the development of a new generation of anti-HIV agents, since these …
High-Throughput HIV–Cell Fusion Assay for Discovery of Virus Entry Inhibitors
… data further support the utility of our 384-well fusion assay for HTS for HIV-1 entry inhibitors.
… for HTS, we evaluated the effect of the highly selective P2X1 receptor inhibitor, NF279, 65 on …
… for HTS, we evaluated the effect of the highly selective P2X1 receptor inhibitor, NF279, 65 on …
Discovery of small-molecule human immunodeficiency virus type 1 entry inhibitors that target the gp120-binding domain of CD4
Q Yang, AG Stephen, JW Adelsberger… - Journal of …, 2005 - Am Soc Microbiol
… CD4 CDR2-targeting small molecule HIV entry inhibitors is its potential interference with
host T-… a prototype of a new class of HIV-1 entry inhibitors that can break down the gp120-CD4 …
host T-… a prototype of a new class of HIV-1 entry inhibitors that can break down the gp120-CD4 …
Discovery of small molecule entry inhibitors targeting the fusion peptide of SARS-CoV-2 spike protein
… studies of our previously identified fusion inhibitor chlorcyclizine, we performed a … of entry
inhibitors targeting the FP. The compounds were evaluated in the pseudoparticle viral entry …
inhibitors targeting the FP. The compounds were evaluated in the pseudoparticle viral entry …
[HTML][HTML] Advances in the development of entry inhibitors for sialic-acid-targeting viruses
… We discuss current modes of treatment for these viruses and highlight advances in the
development of entry inhibitors, if applicable. The chemical structures of the entry inhibitors …
development of entry inhibitors, if applicable. The chemical structures of the entry inhibitors …
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