[PDF][PDF] Systems biology and systems chemistry: new directions for drug discovery
JB Brown, Y Okuno - Chemistry & biology, 2012 - cell.com
… in refining models about polypharmacology and chemical biology. Although the ability to …
knowledge of chemical biology, systems chemistry, polypharmacology, systems biology, …
knowledge of chemical biology, systems chemistry, polypharmacology, systems biology, …
Systems-level chemical biology to accelerate antibiotic drug discovery
… Accordingly, the stage has been set for a shift to a systems-level perspective. This shift has
been catalyzed by new technology and methods in systems and chemical biology that aim to …
been catalyzed by new technology and methods in systems and chemical biology that aim to …
Target identification and mechanism of action in chemical biology and drug discovery
M Schenone, V Dančík, BK Wagner… - … chemical biology, 2013 - nature.com
… Modern chemical biology and drug discovery each seek to identify new small molecules
that potently and selectively modulate the functions of target proteins. Historically, nature has …
that potently and selectively modulate the functions of target proteins. Historically, nature has …
[PDF][PDF] Targeted protein degradation: from chemical biology to drug discovery
PM Cromm, CM Crews - Cell chemical biology, 2017 - cell.com
… This approach offers the potential to reach beyond the limitations of traditional drug discovery
… need to be connected to inhibition of the POI since it induces its removal from the system. …
… need to be connected to inhibition of the POI since it induces its removal from the system. …
Fragment-based approaches in drug discovery and chemical biology
DE Scott, AG Coyne, SA Hudson, C Abell - Biochemistry, 2012 - ACS Publications
… The discovery of new molecules for modulating biological function is a key motivation in
chemical biology and the primary focus in drug discovery programs. Over the past two decades, …
chemical biology and the primary focus in drug discovery programs. Over the past two decades, …
Bead-based screening in chemical biology and drug discovery
VV Komnatnyy, TE Nielsen, K Qvortrup - Chemical communications, 2018 - pubs.rsc.org
… chemical biology, in particular synthesis of peptides and peptidomimetics for probing
biological … to address long-standing problems in Chemical Biology. Her research efforts aim at …
biological … to address long-standing problems in Chemical Biology. Her research efforts aim at …
Systems biology in drug discovery
EC Butcher, EL Berg, EJ Kunkel - Nature biotechnology, 2004 - nature.com
… drug discovery pipelines; but screening was still in the setting of complex disease biology, …
or indirectly from such early 'systems biology'-based drug discovery. In the interest of speed …
or indirectly from such early 'systems biology'-based drug discovery. In the interest of speed …
[HTML][HTML] Stereochemical diversity as a source of discovery in chemical biology
… in chemical biology and drug discovery. Here we review the state of the field in the context
of harnessing chirality as a source of chemical information at the chemistry-biology interface. …
of harnessing chirality as a source of chemical information at the chemistry-biology interface. …
[PDF][PDF] Lessons from the past and charting the future of marine natural products drug discovery and chemical biology
WH Gerwick, BS Moore - Chemistry & biology, 2012 - cell.com
… are very useful in cell biology and pharmacological research. Early discoveries along these
lines … Success Stories from Marine Chemical Biology We have witnessed a transformation in …
lines … Success Stories from Marine Chemical Biology We have witnessed a transformation in …
Exploration of chemical biology approaches to facilitate the discovery and development of novel antibiotics
RR Miranda, A Parthasarathy… - Frontiers in Tropical …, 2022 - frontiersin.org
… discovery that are chemical biology-focused. These include the design and application of
chemical … ’s metabolism, chemical probes are powerful tools in drug discovery that can help …
chemical … ’s metabolism, chemical probes are powerful tools in drug discovery that can help …
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