… in refining models about polypharmacology and chemical biology. Although the ability to …
knowledge of chemical biology, systems chemistry, polypharmacology, systems biology, …

… Accordingly, the stage has been set for a shift to a systems-level perspective. This shift has
been catalyzed by new technology and methods in systems and chemical biology that aim to …

… Modern chemical biology and drug discovery each seek to identify new small molecules
that potently and selectively modulate the functions of target proteins. Historically, nature has …

… This approach offers the potential to reach beyond the limitations of traditional drug discovery
… need to be connected to inhibition of the POI since it induces its removal from the system. …

… The discovery of new molecules for modulating biological function is a key motivation in
chemical biology and the primary focus in drug discovery programs. Over the past two decades, …

… chemical biology, in particular synthesis of peptides and peptidomimetics for probing
biological … to address long-standing problems in Chemical Biology. Her research efforts aim at …

… drug discovery pipelines; but screening was still in the setting of complex disease biology, …
or indirectly from such early 'systems biology'-based drug discovery. In the interest of speed …

… in chemical biology and drug discovery. Here we review the state of the field in the context
of harnessing chirality as a source of chemical information at the chemistry-biology interface. …

… are very useful in cell biology and pharmacological research. Early discoveries along these
lines … Success Stories from Marine Chemical Biology We have witnessed a transformation in …

… discovery that are chemical biology-focused. These include the design and application of
chemical … ’s metabolism, chemical probes are powerful tools in drug discovery that can help …