Role of chemical biology in tuberculosis drug discovery and diagnosis

K Kolbe, SK Veleti, EE Johnson, YW Cho… - ACS infectious …, 2018 - ACS Publications
… In this review, we highlight recent studies in which chemical probes and chemical biology
approaches were utilized for the study of Mtb. These chemical probes can be classified as …

Carboranes in drug discovery, chemical biology and molecular imaging

A Marfavi, P Kavianpour, LM Rendina - Nature Reviews Chemistry, 2022 - nature.com
biological receptors make carboranes exquisite frameworks in the design of probes for chemical
biology, … new design tools in medicinal chemistry and chemical biology, showcasing the …

Cysteine-mediated redox signaling: chemistry, biology, and tools for discovery

CE Paulsen, KS Carroll - Chemical reviews, 2013 - ACS Publications
… More recently, chemical biology approaches have facilitated the development of small
molecule- and protein-based methods for direct detection of distinct oxidative cysteine …

Drug‐Like Protein Protein Interaction Modulators: Challenges and Opportunities for Drug Discovery and Chemical Biology

BO Villoutreix, MA Kuenemann, JL Poyet… - Molecular …, 2014 - Wiley Online Library
… tools that assist drug discovery and chemical biology have been … out in the field of
computational biology and chemistry. … hit discovery on two recently investigated biological

[HTML][HTML] Phenotypic chemical biology for predicting safety and efficacy

EL Berg - Drug Discovery Today: Technologies, 2017 - Elsevier
chemical probes, is a direct and efficient approach for establishing disease relevance.
Chemical … When applied at scale, phenotypic chemical biology advances our understanding of …

Development and application of high‐performance affinity beads: toward chemical biology and drug discovery

S Sakamoto, Y Kabe, M Hatakeyama… - The Chemical …, 2009 - Wiley Online Library
… a chemical screening system using our affinity beads. We hope that utilization of the affinity
beads will contribute to the progress of research in chemical biology. … of our chemical biology

FAF-Drugs2: free ADME/tox filtering tool to assist drug discovery and chemical biology projects

D Lagorce, O Sperandio, H Galons, MA Miteva… - BMC …, 2008 - Springer
… of finding molecules that could enter the drug discovery process or that could help to explore
… A compound collection may be prepared for a chemical biology project or for drug discovery

Drug discovery using chemical systems biology: repositioning the safe medicine Comtan to treat multi-drug and extensively drug resistant tuberculosis

SL Kinnings, N Liu, N Buchmeier… - … computational biology, 2009 - journals.plos.org
… In the present study we demonstrate the efficiency and efficacy of our chemical systems
biology approach through the discovery of safe chemical compounds with the potential to treat …

In silico predictions of hERG channel blockers in drug discovery: from ligand-based and target-based approaches to systems chemical biology

O Taboureau, F Steen Jorgensen - Combinatorial Chemistry & …, 2011 - ingentaconnect.com
… on drugs inducing potentially long-QT syndrome and arrhythmia will be discussed as a new
perspective for a better understanding of the drug responses in systems chemical biology. …

Diversity-oriented synthetic strategies applied to cancer chemical biology and drug discovery

I Collins, AM Jones - Molecules, 2014 - mdpi.com
… , or in structure-based drug discovery when the first scaffold discovered lacks synthetically
… in Figure 1; starting with chemical probe discovery from DOS libraries put through screens …