… a role for IgM antibodies in MS, such as the correlation of “de novo” intrathecal C3 synthesis
and IgM synthesis in MS.6 In addition, a correlation between local IgM synthesis and myelin …

… We also studied whether oligoclonal IgM … Disease course of 15 patients with oligoclonal
IgM against myelin lipids and 33 patients lacking them was followed. Patients with anti-lipid IgM …

… markers related to the different MS courses. In this line, we have … disease course [7–10].
These results have been recently confirmed by other authors studying intrathecal IgM synthesis …

… As no prognostic biological markers are currently available for multiple sclerosis, we
recommend further studies on the intrathecal IgM synthesis. Indeed, whatever the pathological …

… disease course. Only 2 of the 11 patients who showed a benign disease course had ITMS
(IgM+… The remaining nine patients with benign MS lacked ITMS (IgM−, empty bars). The seven …

… bands in control subjects and in subjects with different neurologic diseases. We found …
disease onset. These data suggest that ITMS is present in patients with a worse disease course. …

… Intrathecal IgM synthesis in neurological disease is part of the disease-related IgG/IgA/IgM …
This is confirmed by the individual time course of intrathecal IgM synthesis in 16 patients in …

… According to our findings, intrathecal IgM synthesis is associated with a worse long-term
prognosis. It also correlates with a higher relapse rate, greater disability, and worse MRI …

… IgM synthesis (ITMS) is an optional test in the diagnostic workup of MS. As it can also occur
in other inflammatory and infectious diseases … and an unfavourable disease course. Therefore…

… This study provides Class II evidence that lipid-specific IgM oligoclonal bands can predict
progression from CIS to MS and a worse disease course over a follow-up of at least 2 years. …