… We selected in total 65 (candidate) POAG disease genes and proceeded to … in disease
state. We found that the proteins corresponding to these 65 (candidate) POAG disease genes …

… the vast genetic variation more manageable (Section 7). Subsequently, we present experimental
approaches that take into account these matters and that might be employed to develop …

… studies, has now been applied to a vast range of common complex diseases. Resolution
of the genetic architecture of each disease, then, has proceeded within the resources of each …

… To succeed in finding complex disease genes, a study must … on the allelic architecture of
complex disease genes, because this is … For the vast majority of Mendelian diseases, the overall …

… cloning disease genes for monogenic disorders, the architects of the projects reasoned that
complex human diseases … However, the vast majority of these diseases displayed a diverse …

… -specific functional modules, which comprise a comprehensive network of known genetic
diseases. These investigators also demonstrated that the vast majority of disease genes are …

… identified through common variants, since we remain ignorant of the full complexity of the
biology in which most genes function. Thus, more genes of key biological relevance have likely …

… This led Kimura to propose that virtually all extant chromosomal genetic variation was
neutral, because the vast majority of functional mutations would be deleterious and removed by …

… the importance of the genetic factors. To predict the risk of a complex disease for a healthy
… can we draw from these recent studies about the genetic architecture of complex diseases? …

… information about the genetic basis of complex disease, but … reveal processes underlying
disease associations. Advances … vast nonfunctional sequences and linking them to their target …