… disease pathogenesis may translate into identification of new therapeutic targets, thus facilitate
drug … and growth factors involved in disease pathogenesis may require a combination of …

… between genomics and drug development — one we argue will … relationship between genomics
and drug development. Next, … to influence both drug development and drug use. We end …

… models of inflammatory diseases, suggesting that pharmacological modulation of the
resolution process may be useful for the treatment of chronic inflammatory diseases in humans. …

A wide variety of mechanisms of anti-rheumatic action have been proposed for antimalarial
agents. The molecular actions of chloroquine have been most thoroughly studied in vitro and …

… one-third of drug candidates and is a major contributor to the high cost of drug development,
particularly when … The causes of drug toxicity can be classified in several ways and include …

… a set of “rights” for AD drug development which are aligned with precision drug development.
We consider lessons derived from drug development across several fields as well as …

… greater understanding of disease mechanisms could bring such a situation nearer to reality.
… to understanding the disease has led to the development of drugs that target specific …

… We discuss trial infrastructure changes that may accelerate clinical trials and drug
development. Our goal is to provide insight into the drug development process and to help drug …

… We review the pipeline of drugs … mechanisms of action. We review our annual pipeline
reports for the past 5 years to provide longitudinal insight into clinical trials and drug development …

… site for drug development, the pharmaceutical industry has dedicated approximately one
third of new drug development programs over the last decade to the development of protein …