… The role of sex hormones is currently less established, although some data exist suggesting
that they might also play a role in the phenotypic manifestations of Brugada syndrome. For …

… SCN5A is the only gene linked to the Brugada syndrome so far, and data on genotype–phenotype
relationships in clinical studies are, therefore, limited. Smits and co-workers 24 …

… Brugada Syndrome Our understanding of Brugada syndrome (BrS) has evolved since the
syndrome … diagnosis has traditionally required the exclusion of overt structural heart disease. …

… Since its description, the Brugada Syndrome (BrS) has gained increased scientific interest as
a … Brugada syndrome is believed to be a genetic disease, although the majority of clinically …

… disease.This review provides a summary of what is currently known about Brugada syndrome
… In fact, the decrease in sodium currents can lead to both phenotypes (Brugada syndrome …

… Brugada syndrome (BS) has been defined as an autosomal dominant disease with incomplete
… channel associated with the clinical phenotype has further sustained the definition of the …

… conduction system disease; however, pathogenic variants that are associated with both
diseases in … CACNB2 No phenotypes other than Brugada syndrome are known to be caused by …

… of the L-type calcium channel, which reduce the L-type calcium current (I CaL ), have been
associated with the Brugada phenotype in combination with a relatively short QT interval. …

… 5 but as a distinct disease entity, Brugada and Brugada 1 were the first to report 8 patients …
determining the Brugada phenotype should be questioned 12 and ought to be reconsidered. …

… Brugada syndrome (BrS) is a genetic arrhythmia syndrome, which confers an increased risk
of sudden cardiac death. The phenotypic manifestation of the disease (ECG … This phenotypic …