The coming of age of the angiotensin hypothesis in Alzheimer's disease: progress toward disease prevention and treatment?

PG Kehoe - Journal of Alzheimer's Disease, 2018 - content.iospress.com
… AD and gives credence to the angiotensin hypothesis for AD. Converging evidence …
hypothesis of AD that continues to gain support. In the last two decades, the angiotensin hypothesis

Tissue angiotensin and pathobiology of vascular disease: a unifying hypothesis

VJ Dzau - Hypertension, 2001 - Am Heart Assoc
… lead to vascular disease. Indeed, recent clinical trials of ACE inhibitors have consistently …
class of agents in treating and preventing cardiovascular disease, with impressive reductions in …

Cerebroprotection mediated by angiotensin II: a hypothesis supported by recent randomized clinical trials

A Fournier, FH Messerli, JM Achard… - Journal of the American …, 2004 - jacc.org
… thereby preventing Charcot-… disease, and our hypothesis of cerebroprotection by AT2
receptor activation should be tested by a head-to-head comparison of an ARB with an ACE inhibitor

The renin-angiotensin system and antihypertensive drugs in Alzheimer's disease: current standing of the angiotensin hypothesis?

PG Kehoe, PA Passmore - Journal of Alzheimer's Disease, 2012 - content.iospress.com
… greater scope for disease prevention than any currently … This review explores the hypothesis
that angiotensin II (Ang II… clinical evidence that supports this hypothesis. It also discusses …

Tissue renin–angiotensin systems: a unifying hypothesis of metabolic disease

J Skov, F Persson, J Frøkiær… - Frontiers in …, 2014 - frontiersin.org
… to some extent can prevent metabolic disease. Furthermore, an … The primary effector hormone
of the RAS, angiotensin II, … Based on these observations, we hypothesize that an activated …

Hypothesis regarding the pathophysiological role of alternative pathways of angiotensin II formation in atherosclerosis

K Arakawa, H Urata - Hypertension, 2000 - Am Heart Assoc
… in the development of hypertensive heart disease, congestive heart failure, and … ACE inhibitors
improved the morbidity and mortality rates of patients with various cardiovascular diseases

Unique cardioprotective potential of angiotensin converting enzyme inhibitors: a hypothesis still to be tested on humans

J McMurray, J MacLenachan, HJ Dargie - Journal of Hypertension, 1991 - journals.lww.com
… effect of lowering blood pressure on coronary artery disease. The assumption that coronary
events are not … heart failure as ACE inhibitors do not prevent or reverse fluid retention [4546]. …

Mast cells activate the renin angiotensin system and contribute to migraine: a hypothesis

H Ba'albaki, A Rapoport - Headache: The Journal of Head and …, 2008 - Wiley Online Library
hypothesis may help explain the association between migraine and cardiovascular disease
… an important target in migraine prevention, further hypothesis testing and confirmation of the …

Hypothesis: ACE2 modulates blood pressure in the mammalian organism

Y Yagil, C Yagil - Hypertension, 2003 - Am Heart Assoc
… and contribution to cardiovascular disease in general, and to … arm of the renin-angiotensin
system, which depends heavily … becomes a primary target for the prevention and treatment of …

A hypothesis regarding the function of angiotensin peptides in the brain

CM Ferrario, RAS Santos, KB Brosnihan… - … Hypertension. Part A …, 1988 - Taylor & Francis
… and separate enzymatic pathways for the production of bioactive angiotensin peptides. While
we intend to investigate this hypothesis further, our data may encourage others to provide …