… To direct progression of compound during the drug discovery process, drug discovery
manuals for each disease are prepared to define key decision points and provide objective …

… Broadly, the modern drug discovery process includes identification of disease to be treated
and its unmet medical need, selection of a druggable molecular target and its validation, in …

… High-throughput screening platform for natural product-based drug discovery against 3
neglected tropical diseases: human African trypanosomiasis, leishmaniasis, and Chagas disease…

… , and more work is needed to discover safe and effective therapies for patients with Chagas
disease and leishmaniasis. Advances in tools for drug discovery and novel insights into the …

… However, the main promise of molecular biology for drug discovery lies in the potential to
understand disease processes at the molecular (genetic) level and to determine the optimal …

… the ‘quo vadis’ in Alzheimer's disease drug discovery at the beginning of the new millennium…
innovative molecular probes or drug candidates. In particular, the discovery of endosome-…

… The paradigm seeks to combine the advantages of rational drug discovery with a strong
physiology/disease-based approach in order to overcome some of the weaknesses of both of …

… These data provide promising evidence that VX-765 may be a viable candidate for the
treatment of inflammatory diseases. However, no recent development of VX-765 for the treatment …

… of the biology and pathophysiology of rare diseases, combined with rapid advances in drug
discovery technologies, will bring us closer to the discovery of much-needed new treatments. …

… In this review, we have discussed the different drug discovery approaches used for Chagas
disease, as well as some drug targets explored in the last few years. In this context, we have …