… review: pH-modified solid dispersion, in which pH modifiers are … of the pH the pH modifiers
in the solid dispersion system … , microenvironmental pH, and/or release rate of pH modifiers, …

… In the present study, SD-Eud/DP/TA was developed with the combination of pH-modifier
technology and solid dispersion technology. TA is the most promising pH-modifier among the …

… dispersion formulations with HMPCAS LG as a recrystallization inhibitor carrier, with and
without the incorporation of pH modifiers. … The impact of pH modifiers on the TEL solubility at pH …

… addition of pH-modifier in the amorphous SD formulations could affect the physical stability
of the dispersion, so suitable acid or base should be selected as a potential pH-modifier upon …

… The shells were not only filled with GLC solid dispersion but also pH modifiers. Unlike IR
formulations, sodium carbonate was selected for dual purpose of osmogent and effervescence …

… For drugs with pH-dependent solubility, micro-environmental pH-modifying solid dispersion
(… their solubility by adding alkalizers or acidifiers as pH-modifier [11]. However, SD …

… rate at pH 6.8 than the acid-free DP formulation. These four pH-modifiers were weak acids
… possibility to act as more potent acidic pH-modifiers than these four acids used previously. …

… pH modifiers can be added to manipulate the microenvironmental pH (pH M ) that can alter
the release rate of the pH… increase the solubility by modulating its pH M . With the increase in …

… -modifier in the formulation, leading to pH-independent … solid dispersion (ASD) of CAR
(CAR-ASD) with pH-modifiers for … CAR-ASD formulations with six pH-modifiers were prepared, …

… Results: The immediate release solid dispersions containing the pH modifier greatly …
compared with the immediate release solid dispersions. The pH modifier played an important role in …