DissolvIt: An In Vitro Method for Simulating the Dissolution and Absorption of Inhaled Dry Powder Drugs in the Lungs
P Gerde, M Malmlöf, L Havsborn… - Assay and drug …, 2017 - liebertpub.com
… over time and the remaining drug in the barrier at the end of … dissolution/absorption profiles
in DissolvIt. This study indicates that DissolvIt simulates dissolution and absorption of drugs in …
in DissolvIt. This study indicates that DissolvIt simulates dissolution and absorption of drugs in …
[HTML][HTML] Dissolution and absorption of inhaled drug particles in the lungs
… dissolution systems and absorption models, which have been developed to evaluate dry
powder … , various in vitro dissolution testing methods developed for dry powder particles, and …
powder … , various in vitro dissolution testing methods developed for dry powder particles, and …
Dissolution enhancement of drugs. Part I: technologies and effect of carriers
… process of absorption of drug from oral route dissolution is … drug powder is therefore
deagglomerated in the dry state. This may be used to increase the dissolution rate of drug powders …
deagglomerated in the dry state. This may be used to increase the dissolution rate of drug powders …
Dissolution testing as a prognostic tool for oral drug absorption: dissolution behavior of glibenclamide
R Löbenberg, J Krämer, VP Shah, GL Amidon… - Pharmaceutical …, 2000 - Springer
… , the choice of a suitable dissolution medium Tool for Oral Drug Absorption: … dissolution of
two drug powders was highly dependent process in vivo and to predict oral drug absorption (9,…
two drug powders was highly dependent process in vivo and to predict oral drug absorption (9,…
Drug dissolution: significance of physicochemical properties and physiological conditions
SS Jambhekar, PJ Breen - Drug Discovery Today, 2013 - Elsevier
… drug dissolution characteristics of powders. Figure 3 represents a typical drug dissolution
profile for the amount of drug dissolved … dissolution limitations to the oral absorption of drugs in …
profile for the amount of drug dissolved … dissolution limitations to the oral absorption of drugs in …
Dry powder inhalers: An overview of the in vitro dissolution methodologies and their correlation with the biopharmaceutical aspects of the drug products
SP Velaga, J Djuris, S Cvijic, S Rozou, P Russo… - European Journal of …, 2018 - Elsevier
… On the other hand, prolonged dissolution and slow absorption can increase drug residence
time in the airways and favor local therapeutic effect, depending on the deposition site and …
time in the airways and favor local therapeutic effect, depending on the deposition site and …
One-step preparation of drug-containing microparticles to enhance the dissolution and absorption of poorly water-soluble drugs using a 4-fluid nozzle spray drier
T Mizoe, S Beppu, T Ozeki, H Okada - Journal of controlled release, 2007 - Elsevier
… of EZ from the EZ/LAC and EZ/MAN microparticles was markedly faster than that from EZ
powder, and the dissolution was faster at lower ratios of EZ. Considering the crystalline state of …
powder, and the dissolution was faster at lower ratios of EZ. Considering the crystalline state of …
[HTML][HTML] Nanosizing of drugs: effect on dissolution rate
… absorption process is limited by drug dissolution rate in gastrointestinal media. Therefore,
enhancement of the dissolution rate of these drugs … drug powder transfer to an ultrafine powder …
enhancement of the dissolution rate of these drugs … drug powder transfer to an ultrafine powder …
Enhancement of the dissolution rate and oral absorption of a poorly water soluble drug by formation of surfactant-containing microparticles
SM Wong, IW Kellaway, S Murdan - International Journal of Pharmaceutics, 2006 - Elsevier
… dissolution rate and subsequently the oral absorption and bioavailability of a model poorly
water-soluble drug… The powder collected was again stored in a desiccator until it was ready to …
water-soluble drug… The powder collected was again stored in a desiccator until it was ready to …
Dissolution and absorption modeling: model expansion to simulate the effects of precipitation, water absorption, longitudinally changing intestinal permeability, and …
KC Johnson - Drug development and industrial pharmacy, 2003 - Taylor & Francis
… dissolution conditions and changing drug particle surface area to give a more realistic simulation
of drug dissolution in … the model to handle polydisperse drug powders, particle size and …
of drug dissolution in … the model to handle polydisperse drug powders, particle size and …
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