… dissolution rate is directly proportional to solubility of drugs. Drugs with low aqueous solubility
have low dissolution rates … The poor solubility and poor dissolution rate of poorly water …

… Low dissolution rate influenced by poor aqueous solubility might render low oral
bioavailability of such compounds. This is particularly important in oral drug administration where …

… solubility and dissolution rate in biorelevant dissolution media (BDM) with the purpose of
investigating which molecular structures gain most in solubility when dissolved … the solubility in …

… field represents a hopeful set of pharmaceutical materials offering the prospect of better
alternatives to optimize drug physical properties and biopharmaceutical issues such as solubility…

… having poorly aqueous solubility are increasingly … poor solubility [1]. It is well known that
drug efficacy can be severely limited by poor aqueous solubility, leading to low dissolution rate …

… with poor aqueous solubility and dissolution rate has grown … In a biopharmaceutical context,
‘poor solubility’ needs further … the highest dose strength cannot be dissolved in 250 ml in the …

… as poor solubility is generally associated to poor dissolution characteristics and thus to poor
… Saturation solubility and dissolution characteristics were investigated and compared to the …

… Drug absorption from the gastrointestinal tract can be limited by a variety of factors, most
significant contributors being poor aqueous solubility and poor membrane permeability of the …

… shows poor solubility and high permeability. It is obvious that for class II drugs the low ability
to dissolve is a more important limitation to their overall rate … solubility or dissolution rate 15. …

… The solubility, bioavailability and dissolution rate of … a poor water soluble drug with solubility
of 20 μg/ml of water. Because of low aqueous solubility, it has low dissolution rate and poor …